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Intramuscular vaccination with Strangvac is safe and induces protection against equine strangles caused by Streptococcus equi

Robinson, Carl and Waller, Andrew S. and Frykberg, Lars and Flock, Margareta and Zachrisson, Olof and Guss, Bengt and Flock, Jan-Ingmar (2020). Intramuscular vaccination with Strangvac is safe and induces protection against equine strangles caused by Streptococcus equi. Vaccine. 38 , 4861-4868
[Journal article]

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Abstract

The equine disease strangles, caused by Streptococcus equi, remains a major cause of welfare and economic cost to the global horse industry. Here we report the safety, immunogenicity and efficacy of a novel multi-component chimeric fusion protein vaccine, called Strangvac, when administered to ponies via the intramuscular route. Across the four studies, Strangvac was safe and induced robust antibody responses towards the vaccine components in blood serum and the nasopharynx, which were boosted by revaccination up to 12 months after a primary course of 2 vaccinations 4 weeks apart. The vaccine response did not cross-react with a commercial strangles iELISA, which identifies horses that have been exposed to S. equi, demonstrating that it was possible to differentiate infected from vaccinated animals (DIVA). Following challenge with S. equi strain 4047 (Se4047), all 36 control ponies that had received an adjuvant-only placebo vaccine developed clinical signs of strangles. In contrast, intramuscular vaccination with Strangvac protected ponies significantly from challenge with Se4047 at two weeks (5 of 16 ponies protected (31%), P = 0.04) and two months (7 of 12 ponies protected (58%), P = 0.0046 (including pooled control data) after second vaccination. Optimal protection (15 of 16 ponies protected (94%), P < 0.0001) was observed following challenge at two weeks post-third vaccination. Our data demonstrate that Strangvac is safe, has DIVA capability and provides a rapid onset of protective immunity against strangles. We conclude that Strangvac is a valuable tool with which to protect horses from strangles, particularly during high-risk periods, whilst maintaining the mobility of horse populations as required by the global equine industry. (C) 2020 The Authors. Published by Elsevier Ltd.

Authors/Creators:Robinson, Carl and Waller, Andrew S. and Frykberg, Lars and Flock, Margareta and Zachrisson, Olof and Guss, Bengt and Flock, Jan-Ingmar
Title:Intramuscular vaccination with Strangvac is safe and induces protection against equine strangles caused by Streptococcus equi
Year of publishing :2020
Volume:38
Page range:4861-4868
Number of Pages:8
Publisher:Elsevier
ISSN:0264-410X
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Strangles, Streptococcus equi, Recombinant, Fusion, Vaccine
URN:NBN:urn:nbn:se:slu:epsilon-p-106800
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-106800
Additional ID:
Type of IDID
DOI10.1016/j.vaccine.2020.05.046
Web of Science (WoS)000540831900011
ID Code:17295
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:20 Aug 2020 07:59
Metadata Last Modified:20 Aug 2020 07:59

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