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Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos)

Jorgensen, Peter Godsk and Evans, Alina and Kindberg, Jonas and Olsen, Lisbeth Hoier and Galatius, Soren and Frobert, Ole (2020). Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos). Scientific Reports. 10 , 247 , 1-9
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Abstract

During six months of annual hibernation, the brown bear undergoes unique physiological changes to adapt to decreased metabolic rate. We compared cardiac structural and functional measures of hibernating and active bears using comprehensive echocardiography. We performed echocardiography on 13 subadult free-ranging, anaesthetised Scandinavian brown bears (Ursus arctos) during late hibernation and in early summer. Mean heart rate was 26 beats per minute (standard deviation (SD): 8) during hibernation vs 71 (SD: 14) during active state. All left ventricular (LV) systolic and diastolic measures were decreased during hibernation: mean ejection fraction: 44.2% (SD: 6.0) active state vs 34.0 (SD: 8.1) hibernation, P = 0.001; global longitudinal strain: -11.2% (SD: 2.0) vs -8.8 (SD: 3.3), P = 0.03; global longitudinal strain rate: -0.82 (SD: 0.15) vs -0.41 (SD: 0.18), P < 0.001; septal e': 9.8 cm/s (SD: 1.8) vs 5.2 (SD: 2.7), P < 0.001. In general, measures of total myocardial motion (ejection fraction and global longitudinal strain) were decreased to a lesser extent than measures of myocardial velocities. In the hibernating brown bear, cardiac adaptation included decreased functional measures, primarily measures of myocardial velocities, but was not associated with cardiac atrophy. Understanding the mechanisms of these adaptations could provide pathophysiological insight of human pathological conditions such as heart failure.

Authors/Creators:Jorgensen, Peter Godsk and Evans, Alina and Kindberg, Jonas and Olsen, Lisbeth Hoier and Galatius, Soren and Frobert, Ole
Title:Cardiac adaptation in hibernating, free-ranging Scandinavian Brown Bears (Ursus arctos)
Year of publishing :2020
Volume:10
Article number:247
Number of Pages:9
Publisher:NATURE PUBLISHING GROUP
ISSN:2045-2322
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Zoology
URN:NBN:urn:nbn:se:slu:epsilon-p-107136
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107136
Additional ID:
Type of IDID
DOI10.1038/s41598-019-57126-y
Web of Science (WoS)000551360800003
ID Code:17435
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:10 Sep 2020 08:01
Metadata Last Modified:10 Sep 2020 08:01

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