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A low transition temperature mixture for the dispersive liquid-liquid microextraction of pesticides from surface waters

Tomai, Pierpaolo and Lippiello, Anna and D'Angelo, Paola and Persson, Ingmar and Martinelli, Andrea and Di Lisio, Valerio and Curini, Roberta and Fanali, Chiara and Gentili, Alessandra (2019). A low transition temperature mixture for the dispersive liquid-liquid microextraction of pesticides from surface waters. Journal of Chromatography A. 1605 , 360329
[Research article]

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Abstract

This paper illustrates the development of a procedure based on the use of a low transition temperature mixture (LTTM) for the dispersive liquid-liquid microextraction (DLLME) of fungicides, insecticides and acaricides from surface waters. The LTTM preparation involves the heat-mixing of choline chloride and acetylsalicylic acid in a molar ratio 1:2 (ChCl(ASA)(2)). The resulting mixture appears as a clear viscous liquid at room-temperature, denser than water (1.20 +/- 0.01 g mL(-1)). For its characterization, differential scanning calorimetry (DSC) provided crucial evidence to classify it as a LTTM rather than as a deep eutectic solvent (DES) since it revealed an intense glass transition at -37 degrees C. Large-angle X-ray scattering (LAXS) confirmed the lack of any long-distance order. Due to the LTTM immiscibility with water, an evaluation study was carried out to test ChCl(ASA)(2) as an effective alternative to the conventional chlorinated solvents for DLLME. To this end, 24 pesticides were used as model compounds, extracted from surface water samples (5 mL) and analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The definitive procedure required the optimization of some key parameters such as volume of extracting solvent, type and volume of dispersing solvent, volume of the aqueous sample, LTTM dispersion procedure, and extraction time. Depending on pKa and logP values, recoveries ranged from 18 (for very polar compounds) to 96%, revealing that the ideal candidates for the extraction with ChCl(ASA)(2) are neutral compounds with logP >2. After complete validation, the method was applied to analyze water samples from the River Tiber where dodine and dimetomorph were found at low mu g L-1 concentration levels. (C) 2019 Elsevier B.V. All rights reserved.

Authors/Creators:Tomai, Pierpaolo and Lippiello, Anna and D'Angelo, Paola and Persson, Ingmar and Martinelli, Andrea and Di Lisio, Valerio and Curini, Roberta and Fanali, Chiara and Gentili, Alessandra
Title:A low transition temperature mixture for the dispersive liquid-liquid microextraction of pesticides from surface waters
Series Name/Journal:Journal of Chromatography A
Year of publishing :2019
Volume:1605
Article number:360329
Number of Pages:10
Publisher:ELSEVIER
ISSN:0021-9673
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Accepted version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
(A) Swedish standard research categories 2011 > 1 Natural sciences > 104 Chemical Sciences > Analytical Chemistry
Keywords:Low transition temperature mixture, Deep eutectic solvents, Dispersive liquid-liquid microextraction, Sample preparation, Environmental samples, LC-MS
URN:NBN:urn:nbn:se:slu:epsilon-p-103176
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-103176
Additional ID:
Type of IDID
DOI10.1016/j.chroma.2019.06.050
Web of Science (WoS)000500389200001
ID Code:17454
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Chemistry (until 131231)
Deposited By: SLUpub Connector
Deposited On:10 Feb 2021 08:20
Metadata Last Modified:21 Jun 2021 23:15

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