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Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications

Sun, Rui and Ahlen, Michelle and Tai, Cheuk-Wai and Bajnóczi, Éva and de Kleijne, Fenne and Ferraz, Natalia and Persson, Ingmar and Stromme, Maria and Cheung, Ocean (2020). Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications. Nanomaterials. 10 , 20 , 1-18
[Journal article]

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Abstract

Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization and promising applications in bio-medicine. However, the limited stability and porosity of ACP material restrict its practical applications. A storage stable highly porous ACP with Brunauer-Emmett-Teller surface area of over 400 m(2)/g was synthesized by introducing phosphoric acid to a methanol suspension containing amorphous calcium carbonate nanoparticles. Electron microscopy revealed that the porous ACP was constructed with aggregated ACP nanoparticles with dimensions of several nanometers. Large angle X-ray scattering revealed a short-range atomic order of <20 angstrom in the ACP nanoparticles. The synthesized ACP demonstrated long-term stability and did not crystallize even after storage for over 14 months in air. The stability of the ACP in water and an alpha-MEM cell culture medium were also examined. The stability of ACP could be tuned by adjusting its chemical composition. The ACP synthesized in this work was cytocompatible and acted as drug carriers for the bisphosphonate drug alendronate (AL) in vitro. AL-loaded ACP released 25% of the loaded AL in the first 22 days. These properties make ACP a promising candidate material for potential application in biomedical fields such as drug delivery and bone healing.

Authors/Creators:Sun, Rui and Ahlen, Michelle and Tai, Cheuk-Wai and Bajnóczi, Éva and de Kleijne, Fenne and Ferraz, Natalia and Persson, Ingmar and Stromme, Maria and Cheung, Ocean
Title:Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications
Year of publishing :2020
Volume:10
Article number:20
Number of Pages:18
Publisher:MDPI
ISSN:2079-4991
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 2 Engineering and Technology > 210 Nano Technology > Nano Technology
Keywords:amorphous calcium phosphate, porous materials, cytocompatibility, drug carrier, bisphosphonate
URN:NBN:urn:nbn:se:slu:epsilon-p-104949
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-104949
Additional ID:
Type of IDID
DOI10.3390/nano10010020
Web of Science (WoS)000516825600020
ID Code:17458
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:14 Sep 2020 11:17
Metadata Last Modified:14 Sep 2020 11:17

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