Kumaresan, Arumugam and Das Gupta, Mohua and Datta, Tirtha Kumar and Morrell, Jane
(2020).
Sperm DNA Integrity and Male Fertility in Farm Animals: A Review.
Frontiers in Veterinary Science. 7
, 321
[Article Review/Survey]
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Abstract
The accurate prediction of male fertility is of major economic importance in the animal breeding industry. However, the results of conventional semen analysis do not always correlate with field fertility outcomes. There is evidence to indicate that mammalian fertilization and subsequent embryo development depend, in part, on the inherent integrity of the sperm DNA. Understanding the complex packaging of mammalian sperm chromatin and assessment of DNA integrity could potentially provide a benchmark in clinical infertility. In the era of assisted reproduction, especially whenin-vitrofertilization or gamete intrafallopian transfer or intracytoplasmic sperm injection is used, assessment of sperm DNA integrity is important because spermatozoa are not subjected to the selection process occurring naturally in the female reproductive tract. Although sperm DNA integrity testing measures a significant biological parameter, its precise role in the infertility evaluation in farm animals remains unclear. In this review, the earlier findings on sperm DNA integrity in relation to male fertility are compiled and analyzed. Furthermore, the causes and consequences of sperm DNA damage are described, together with a review of advances in methods for detection of sperm DNA damage, and the prognostic value of sperm DNA quality on male fertility.
Authors/Creators: | Kumaresan, Arumugam and Das Gupta, Mohua and Datta, Tirtha Kumar and Morrell, Jane | ||||||
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Title: | Sperm DNA Integrity and Male Fertility in Farm Animals: A Review | ||||||
Series Name/Journal: | Frontiers in Veterinary Science | ||||||
Year of publishing : | 2020 | ||||||
Volume: | 7 | ||||||
Article number: | 321 | ||||||
Number of Pages: | 15 | ||||||
Publisher: | Frontiers | ||||||
ISSN: | 2297-1769 | ||||||
Language: | English | ||||||
Publication Type: | Article Review/Survey | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science. | ||||||
Keywords: | male infertility, sperm, DNA integrity, epigenetic modifications, prognostic value | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-107173 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107173 | ||||||
Additional ID: |
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ID Code: | 17520 | ||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
Department: | (VH) > Dept. of Clinical Sciences | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 22 Sep 2020 09:57 | ||||||
Metadata Last Modified: | 15 Jan 2021 19:25 |
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