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Sperm DNA Integrity and Male Fertility in Farm Animals: A Review

Kumaresan, Arumugam and Das Gupta, Mohua and Datta, Tirtha Kumar and Morrell, Jane (2020). Sperm DNA Integrity and Male Fertility in Farm Animals: A Review. Frontiers in Veterinary Science. 7 , 321
[Article Review/Survey]

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Abstract

The accurate prediction of male fertility is of major economic importance in the animal breeding industry. However, the results of conventional semen analysis do not always correlate with field fertility outcomes. There is evidence to indicate that mammalian fertilization and subsequent embryo development depend, in part, on the inherent integrity of the sperm DNA. Understanding the complex packaging of mammalian sperm chromatin and assessment of DNA integrity could potentially provide a benchmark in clinical infertility. In the era of assisted reproduction, especially whenin-vitrofertilization or gamete intrafallopian transfer or intracytoplasmic sperm injection is used, assessment of sperm DNA integrity is important because spermatozoa are not subjected to the selection process occurring naturally in the female reproductive tract. Although sperm DNA integrity testing measures a significant biological parameter, its precise role in the infertility evaluation in farm animals remains unclear. In this review, the earlier findings on sperm DNA integrity in relation to male fertility are compiled and analyzed. Furthermore, the causes and consequences of sperm DNA damage are described, together with a review of advances in methods for detection of sperm DNA damage, and the prognostic value of sperm DNA quality on male fertility.

Authors/Creators:Kumaresan, Arumugam and Das Gupta, Mohua and Datta, Tirtha Kumar and Morrell, Jane
Title:Sperm DNA Integrity and Male Fertility in Farm Animals: A Review
Year of publishing :2020
Volume:7
Article number:321
Number of Pages:15
Publisher:Frontiers
ISSN:2297-1769
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:male infertility, sperm, DNA integrity, epigenetic modifications, prognostic value
URN:NBN:urn:nbn:se:slu:epsilon-p-107173
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107173
Additional ID:
Type of IDID
DOI10.3389/fvets.2020.00321
Web of Science (WoS)000548408500001
ID Code:17520
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:22 Sep 2020 09:57
Metadata Last Modified:22 Sep 2020 09:57

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