Home About Browse Search
Svenska


The chromogranin A-derived peptides catestatin and vasostatin in dogs with myxomatous mitral valve disease

Höglund, Katja and Häggström, Jens and Höglund, Odd and Stridsberg, Mats and Tidholm, Anna and Bersås Ljungvall, Ingrid (2020). The chromogranin A-derived peptides catestatin and vasostatin in dogs with myxomatous mitral valve disease. Acta Veterinaria Scandinavica. 62 , 43 , 1-7
[Journal article]

[img] PDF
754kB

Abstract

Background The protein chromogranin A (CgA) is stored and co-released with catecholamines from the stimulated adrenal glands. Increased plasma concentrations of CgA have been shown in people with heart disease. The aim of the study was to investigate whether plasma concentrations of the CgA-derived biologically active peptides catestatin and vasostatin were associated with the severity of myxomatous mitral valve disease (MMVD) in dogs and to assess potential associations between these blood variables and dog characteristics, echocardiographic variables, heart rate (HR), blood pressure (BP) and plasma N-terminal-proBNP (NT-proBNP) concentration. Sixty-seven privately owned dogs with or without MMVD were included. The dogs underwent physical examination, blood pressure measurement, blood sample collection, and echocardiographic examination. Plasma concentrations of catestatin and vasostatin were analyzed using radioimmunoassay. Results Catestatin concentration decreased with increasing left atrial and ventricular size (R-2 <= 0.09, P <= 0.019), and increased with increasing systolic and diastolic blood pressures (R-2 <= 0.08, P <= 0.038). Regression analyses showed no significant associations for vasostatin. No differences in plasma concentrations of catestatin or vasostatin were found between the disease severity groups used in the study. Conclusions In the present dog population, the catestatin concentration showed weak negative associations with left atrial and ventricular sizes, both of which are known to increase with increasing severity of MMVD. Furthermore, the catestatin concentration showed weak positive associations with blood pressure.

Authors/Creators:Höglund, Katja and Häggström, Jens and Höglund, Odd and Stridsberg, Mats and Tidholm, Anna and Bersås Ljungvall, Ingrid
Title:The chromogranin A-derived peptides catestatin and vasostatin in dogs with myxomatous mitral valve disease
Year of publishing :2020
Volume:62
Article number:43
Number of Pages:7
Publisher:BMC
ISSN:0044-605X
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Canine, Catestatin, Heart, Sympathetic nervous system, Vasostatin
URN:NBN:urn:nbn:se:slu:epsilon-p-107749
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107749
Additional ID:
Type of IDID
DOI10.1186/s13028-020-00541-3
Web of Science (WoS)000560737100001
ID Code:17548
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:06 Oct 2020 07:36
Metadata Last Modified:06 Oct 2020 07:36

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits