Pejler, Gunnar
(2020).
Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors.
Journal of Innate Immunity. 12
, 357-372
[Article Review/Survey]
Full text not available from this repository.
Abstract
Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood. Mast cells are packed with secretory granules, and when they undergo degranulation in response to activation the contents of the granules are expelled to the extracellular milieu. Chymases, neutral serine proteases, are the major constituents of the mast cell granules and are hence released in large amounts upon mast cell activation. Following their release, chymases can cleave one or several of a myriad of potential substrates, and the cleavage of many of these could potentially have a profound impact on the respective pathology. Indeed, chymases have recently been implicated in several pathological contexts, in particular through studies using chymase inhibitors and by the use of chymase-deficient animals. In many cases, chymase has been shown to account for mast cell-dependent detrimental effects in the respective conditions and is therefore emerging as a promising drug target. On the other hand, chymase has been shown to have protective roles in other pathological settings. More unexpectedly, chymase has also been shown to control certain homeostatic processes. Here, these findings are reviewed.
Authors/Creators: | Pejler, Gunnar | ||||||
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Title: | Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors | ||||||
Series Name/Journal: | Journal of Innate Immunity | ||||||
Year of publishing : | 2020 | ||||||
Volume: | 12 | ||||||
Page range: | 357-372 | ||||||
Number of Pages: | 16 | ||||||
ISSN: | 1662-811X | ||||||
Language: | English | ||||||
Publication Type: | Article Review/Survey | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||
Full Text Status: | None | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Cell and Molecular Biology | ||||||
Keywords: | Chymase, Mast cells, Knockout, Inhibitors | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-107825 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107825 | ||||||
Additional ID: |
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ID Code: | 17581 | ||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
Department: | (VH) > Dept. of Anatomy, Physiology and Biochemistry | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 23 Sep 2020 12:30 | ||||||
Metadata Last Modified: | 15 Jan 2021 19:45 |
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