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Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Pejler, Gunnar (2020). Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors. Journal of Innate Immunity. 12 , 357-372
[Article Review/Survey]

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Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood. Mast cells are packed with secretory granules, and when they undergo degranulation in response to activation the contents of the granules are expelled to the extracellular milieu. Chymases, neutral serine proteases, are the major constituents of the mast cell granules and are hence released in large amounts upon mast cell activation. Following their release, chymases can cleave one or several of a myriad of potential substrates, and the cleavage of many of these could potentially have a profound impact on the respective pathology. Indeed, chymases have recently been implicated in several pathological contexts, in particular through studies using chymase inhibitors and by the use of chymase-deficient animals. In many cases, chymase has been shown to account for mast cell-dependent detrimental effects in the respective conditions and is therefore emerging as a promising drug target. On the other hand, chymase has been shown to have protective roles in other pathological settings. More unexpectedly, chymase has also been shown to control certain homeostatic processes. Here, these findings are reviewed.

Authors/Creators:Pejler, Gunnar
Title:Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
Series Name/Journal:Journal of Innate Immunity
Year of publishing :2020
Page range:357-372
Number of Pages:16
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:None
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Cell and Molecular Biology
Keywords:Chymase, Mast cells, Knockout, Inhibitors
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Additional ID:
Type of IDID
Web of Science (WoS)000565750200002
ID Code:17581
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:23 Sep 2020 12:30
Metadata Last Modified:15 Jan 2021 19:45

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