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Chlamydial contribution to anaerobic metabolism during eukaryotic evolution

Stairs, Courtney W. and Dharamshi, Jennah E. and Tamarit Chuliá, Daniel and Eme, Laura and Jorgensen, Steffen L. and Spang, Anja and Ettema, Thijs J. G. (2020). Chlamydial contribution to anaerobic metabolism during eukaryotic evolution. Science Advances. 6 , eabb7258
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Abstract

The origin of eukaryotes is a major open question in evolutionary biology. Multiple hypotheses posit that eukaryotes likely evolved from a syntrophic relationship between an archaeon and an alphaproteobacterium based on H-2 exchange. However, there are no strong indications that modern eukaryotic H-2 metabolism originated from archaea or alphaproteobacteria. Here, we present evidence for the origin of H-2 metabolism genes in eukaryotes from an ancestor of the Anoxychlamydiales-a group of anaerobic chlamydiae, newly described here, from marine sediments. Among Chlamydiae, these bacteria uniquely encode genes for H-2 metabolism and other anaerobiosis-associated pathways. Phylogenetic analyses of several components of H-2 metabolism reveal that Anoxychlamydiales homologs are the closest relatives to eukaryotic sequences. We propose that an ancestor of the Anoxychlamydiales contributed these key genes during the evolution of eukaryotes, supporting a mosaic evolutionary origin of eukaryotic metabolism.

Authors/Creators:Stairs, Courtney W. and Dharamshi, Jennah E. and Tamarit Chuliá, Daniel and Eme, Laura and Jorgensen, Steffen L. and Spang, Anja and Ettema, Thijs J. G.
Title:Chlamydial contribution to anaerobic metabolism during eukaryotic evolution
Year of publishing :2020
Volume:6
Article number:eabb7258
Number of Pages:8
ISSN:2375-2548
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
URN:NBN:urn:nbn:se:slu:epsilon-p-107812
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107812
Additional ID:
Type of IDID
DOI10.1126/sciadv.abb7258
Web of Science (WoS)000563099200016
ID Code:17606
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Aquatic Sciences and Assessment
Deposited By: SLUpub Connector
Deposited On:28 Sep 2020 08:00
Metadata Last Modified:28 Sep 2020 08:01

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