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Plasmodium falciparum gametocyte-induced volatiles enhance attraction of Anopheles mosquitoes in the field

Debebe, Yared and Hill, Sharon and Birgersson, Göran and Tekie, Habte and Ignell, Rickard (2020). Plasmodium falciparum gametocyte-induced volatiles enhance attraction of Anopheles mosquitoes in the field. Malaria Journal. 19 , 327
[Journal article]

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Abstract

BackgroundPlasmodium parasites manipulate the interaction between their mosquito and human hosts. Patients infected with gametocytes attract anopheline mosquitoes differentially compared to healthy individuals, an effect associated with an increased release of attractive volatile cues. This odour-driven manipulation is partly mediated by the gametocyte-specific metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), which induces increased release of select aldehydes and terpenes from red blood cells and results in the enhanced attraction of host-seeking mosquitoes, which are vectors of malaria. This study investigates the effect of the HMBPP-induced volatiles on the attraction of wild Anopheles mosquitoes to humans under field conditions.MethodsThe efficacy of the HMBPP-induced odour blend to attract Anopheles was evaluated in a 4x6 Latin rectangular study design indoors using baited Suna traps. Furthermore, to assess the efficacy of the HMBPP-induced odour blend in (1) augmenting the attractiveness of human odour, and (2) attracting Anopheles mosquitoes in the absence of human odour, a two-choice assay using host decoy traps (HDTs) was used and evaluated using binomial generalized regression.ResultsTraps baited with the HMBPP-induced odour blend attracted and caught both Anopheles arabiensis and Anopheles pharoensis females in a dose-dependent manner in the presence of background human odour, up to 2.5 times that of an unbaited trap. Given a choice between human odour and human odour laden with the HMBPP-induced odour blend, mosquitoes differentially preferred traps augmented with the HMBPP-induced odour blend, which caught twice as many female An. arabiensis. Traps baited with the HMBPP-induced odour blend but lacking the background of human odour were not effective in attracting and catching mosquitoes.ConclusionThe findings of the present study revealed that the HMBPP-induced odour blend, when augmented with human body odour, is attractive to anopheline mosquitoes and could be used as a complementary vector control tool along with existing strategies.

Authors/Creators:Debebe, Yared and Hill, Sharon and Birgersson, Göran and Tekie, Habte and Ignell, Rickard
Title:Plasmodium falciparum gametocyte-induced volatiles enhance attraction of Anopheles mosquitoes in the field
Year of publishing :2020
Volume:19
Article number:327
Number of Pages:7
ISSN:1475-2875
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology
Keywords:(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, HMBPP, Anopheles, Mosquitoes, Attraction
URN:NBN:urn:nbn:se:slu:epsilon-p-108103
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108103
Additional ID:
Type of IDID
DOI10.1186/s12936-020-03378-3
Web of Science (WoS)000569719600004
ID Code:17813
Faculty:LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap
Department:(LTJ, LTV) > Department of Plant Protection Biology
Deposited By: SLUpub Connector
Deposited On:14 Oct 2020 15:00
Metadata Last Modified:14 Oct 2020 15:01

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