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Genome sequence of segmented filamentous bacteria present in the human intestine

Jonsson, Hans and Hugerth, Luisa W. and Sundh, John and Lundin, Eva and Andersson, Anders F. (2020). Genome sequence of segmented filamentous bacteria present in the human intestine. Communications biology. 3 , 485
[Journal article]

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Abstract

Segmented filamentous bacteria (SFB) are unique immune modulatory bacteria colonizing the small intestine of a variety of animals in a host-specific manner. SFB exhibit filamentous growth and attach to the host's intestinal epithelium, offering a physical route of interaction. SFB affect functions of the host immune system, among them IgA production and T-cell maturation. Until now, no human-specific SFB genome has been reported. Here, we report the metagenomic reconstruction of an SFB genome from a human ileostomy sample. Phylogenomic analysis clusters the genome with SFB genomes from mouse, rat and turkey, but the genome is genetically distinct, displaying 65-71% average amino acid identity to the others. By screening human faecal metagenomic datasets, we identified individuals carrying sequences identical to the new SFB genome. We thus conclude that a unique SFB variant exists in humans and foresee a renewed interest in the elucidation of SFB functionality in this environment. Hans Jonsson et al. report the metagenomic reconstruction of the genome of a potentially immune modulatory segmented filamentous bacteria (SFB) from a human ileostomy sample. They demonstrate that the genome clusters closely with SFB genomes from other species. They also detect the unique SFB variant in human faecal metagenomics datasets.

Authors/Creators:Jonsson, Hans and Hugerth, Luisa W. and Sundh, John and Lundin, Eva and Andersson, Anders F.
Title:Genome sequence of segmented filamentous bacteria present in the human intestine
Year of publishing :2020
Volume:3
Article number:485
Number of Pages:9
ISSN:2399-3642
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area
URN:NBN:urn:nbn:se:slu:epsilon-p-108106
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108106
Additional ID:
Type of IDID
DOI10.1038/s42003-020-01214-7
Web of Science (WoS)000569864300001
ID Code:17814
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:14 Oct 2020 15:00
Metadata Last Modified:14 Oct 2020 15:01

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