Jonsson, Hans and Hugerth, Luisa W. and Sundh, John and Lundin, Eva and Andersson, Anders F.
(2020).
Genome sequence of segmented filamentous bacteria present in the human intestine.
Communications biology. 3
, 485
[Research article]
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Abstract
Segmented filamentous bacteria (SFB) are unique immune modulatory bacteria colonizing the small intestine of a variety of animals in a host-specific manner. SFB exhibit filamentous growth and attach to the host's intestinal epithelium, offering a physical route of interaction. SFB affect functions of the host immune system, among them IgA production and T-cell maturation. Until now, no human-specific SFB genome has been reported. Here, we report the metagenomic reconstruction of an SFB genome from a human ileostomy sample. Phylogenomic analysis clusters the genome with SFB genomes from mouse, rat and turkey, but the genome is genetically distinct, displaying 65-71% average amino acid identity to the others. By screening human faecal metagenomic datasets, we identified individuals carrying sequences identical to the new SFB genome. We thus conclude that a unique SFB variant exists in humans and foresee a renewed interest in the elucidation of SFB functionality in this environment. Hans Jonsson et al. report the metagenomic reconstruction of the genome of a potentially immune modulatory segmented filamentous bacteria (SFB) from a human ileostomy sample. They demonstrate that the genome clusters closely with SFB genomes from other species. They also detect the unique SFB variant in human faecal metagenomics datasets.
Authors/Creators: | Jonsson, Hans and Hugerth, Luisa W. and Sundh, John and Lundin, Eva and Andersson, Anders F. | ||||||
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Title: | Genome sequence of segmented filamentous bacteria present in the human intestine | ||||||
Series Name/Journal: | Communications biology | ||||||
Year of publishing : | 2020 | ||||||
Volume: | 3 | ||||||
Article number: | 485 | ||||||
Number of Pages: | 9 | ||||||
ISSN: | 2399-3642 | ||||||
Language: | English | ||||||
Publication Type: | Research article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-108106 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108106 | ||||||
Additional ID: |
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ID Code: | 17814 | ||||||
Faculty: | NJ - Fakulteten för naturresurser och jordbruksvetenskap | ||||||
Department: | (NL, NJ) > Department of Molecular Sciences | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 14 Oct 2020 15:00 | ||||||
Metadata Last Modified: | 15 Jan 2021 19:22 |
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