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Adipokines as biomarkers of postpartum subclinical endometritis in dairy cows

Pereira, Goncalo and Bexiga, Ricardo and Chagas e Silva, Joao and Silva, Elisabete and Rame, Christelle and Dupont, Joelle and Guo, Yongzhi and Humblot, Patrice and Lopes-da-Costa, Luis (2020). Adipokines as biomarkers of postpartum subclinical endometritis in dairy cows. Reproduction. 160 , 417-430
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Abstract

Adipokines emerged as regulators of metabolism and inflammation in several scenarios. This study evaluated the relationship between adipokines (adiponectin, chemerin and visfatin) and cytological (subclinical) endometritis, by comparing healthy (without), transient (recovered by 45 days postpartum (DPP)) and persistent (until 45 DPP) endometritis cows (n = 49). Cows with persistent endometritis had higher adiponectin concentrations in plasma (at 21 DPP, P < 0.05 and at 45 DPP, P < 0.01) and in uterine fluid (at 45 DPP, P < 0.001), and higher chemerin concentrations in plasma (P < 0.05) and uterine fluid (P < 0.01) at 45 DPP than healthy cows. Cows with persistent endometritis had higher gene transcription in the cellular pellet of uterine fluid and protein expression in the endometrium of these adipokines and their receptors than healthy cows. Adiponedin plasma concentrations allowed to discriminate healthy from persistent endometritis cows, in 87% (21 DPP) and 98% (45 DPP) of cases, and adiponectin and chemerin uterine fluid concentrations at 45 DPP allowed for this discrimination in 100% of cases. Cows with concentrations above the cutoff were a minimum of 3.5 (plasma 21 DPP), 20.4 (plasma 45 DPP), and 33.3 (uterine fluid 45 DPP) times more at risk of evidencing persistent endometritis at 45 DPP than cows with concentrations below the cutoff. Overall, results indicate a relationship between adipokine signalling and the inflammatory status of the postpartum uterus of dairy cows, evidencing that adipokines represent suitable biomarkers of subclinical endometritis, able to predict the risk of persistence of inflammation.

Authors/Creators:Pereira, Goncalo and Bexiga, Ricardo and Chagas e Silva, Joao and Silva, Elisabete and Rame, Christelle and Dupont, Joelle and Guo, Yongzhi and Humblot, Patrice and Lopes-da-Costa, Luis
Title:Adipokines as biomarkers of postpartum subclinical endometritis in dairy cows
Year of publishing :2020
Volume:160
Page range:417-430
Number of Pages:14
ISSN:1470-1626
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-108167
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108167
Additional ID:
Type of IDID
DOI10.1530/REP-20-0183
Web of Science (WoS)000573967700010
ID Code:17864
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:23 Oct 2020 17:40
Metadata Last Modified:24 Oct 2020 05:01

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