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Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography

Amane, Agraw and Belay, Gurja and Nasser, Yao and Kyalo, Martina and Dessie, Tadelle and Kebede, Adebabay and Getachew, Tesfaye and Entfellner, Jean-Baka Domelevo and Edea, Zewdu and Hanotte, Olivier and Tarekegn, Getinet Mekuriaw (2020). Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography. Genes and Genomics. 42 , 1169-1178
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Abstract

Background Ethiopian sheep living in different climatic zones and having contrasting morphologies are a most promising subject of molecular-genetic research. Elucidating their genetic diversity and genetic structure is critical for designing appropriate breeding and conservation strategies. Objective The study was aimed to investigate genome-wide genetic diversity and population structure of eight Ethiopian sheep populations. Methods A total of 115 blood samples were collected from four Ethiopian sheep populations that include Washera, Farta and Wollo (short fat-tailed) and Horro (long fat-tailed). DNA was extracted using Quick-DNA (TM) Miniprep plus kit. All DNA samples were genotyped using Ovine 50 K SNP BeadChip. To infer genetic relationships of Ethiopian sheep at national, continental and global levels, genotype data on four Ethiopian sheep (Adilo, Arsi-Bale, Menz and Black Head Somali) and sheep from east, north, and south Africa, Middle East and Asia were included in the study as reference. Results Mean genetic diversity of Ethiopian sheep populations ranged from 0.352 +/- 0.14 for Horro to 0.379 +/- 0.14 for Arsi-Bale sheep. Population structure and principal component analyses of the eight Ethiopian indigenous sheep revealed four distinct genetic cluster groups according to their tail phenotype and geographical distribution. The short fat-tailed sheep did not represent one genetic cluster group. Ethiopian fat-rump sheep share a common genetic background with the Kenyan fat-tailed sheep. Conclusion The results of the present study revealed the principal component and population structure follows a clear pattern of tail morphology and phylogeography. There is clear signature of admixture among the study Ethiopian sheep populations

Authors/Creators:Amane, Agraw and Belay, Gurja and Nasser, Yao and Kyalo, Martina and Dessie, Tadelle and Kebede, Adebabay and Getachew, Tesfaye and Entfellner, Jean-Baka Domelevo and Edea, Zewdu and Hanotte, Olivier and Tarekegn, Getinet Mekuriaw
Title:Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography
Year of publishing :2020
Volume:42
Page range:1169-1178
Number of Pages:10
ISSN:1976-9571
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:Fat-tail, Genetic diversity, Ovine 50 K SNP, Population structure
URN:NBN:urn:nbn:se:slu:epsilon-p-107719
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-107719
Additional ID:
Type of IDID
DOI10.1007/s13258-020-00984-y
Web of Science (WoS)000559951700001
ID Code:17948
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:27 Oct 2020 11:11
Metadata Last Modified:27 Oct 2020 11:21

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