Home About Browse Search
Svenska


The epidemiology of fighting in group-housed laboratory mice

Theil, Jacob H. and Ahloy-Dallaire, Jamie and Weber, Elin and Gaskill, Brianna N. and Pritchett-Corning, Kathleen R. and Felt, Stephen A. and Garner, Joseph P. (2020). The epidemiology of fighting in group-housed laboratory mice. Scientific Reports. 10 , 16649
[Journal article]

[img] PDF
1MB

Abstract

Injurious home-cage aggression (fighting) in mice affects both animal welfare and scientific validity. It is arguably the most common potentially preventable morbidity in mouse facilities. Existing literature on mouse aggression almost exclusively examines territorial aggression induced by introducing a stimulus mouse into the home-cage of a singly housed mouse (i.e. the resident/intruder test). However, fighting occurring in mice living together in long-term groups under standard laboratory housing conditions has barely been studied. We performed a point-prevalence epidemiological survey of fighting at a research institution with an approximate 60,000 cage census. A subset of cages was sampled over the course of a year and factors potentially influencing home-cage fighting were recorded. Fighting was almost exclusively seen in group-housed male mice. Approximately 14% of group-housed male cages were observed with fighting animals in brief behavioral observations, but only 14% of those cages with fighting had skin injuries observable from cage-side. Thus simple cage-side checks may be missing the majority of fighting mice. Housing system (the combination of cage ventilation and bedding type), genetic background, time of year, cage location on the rack, and rack orientation in the room were significant risk factors predicting fighting. Of these predictors, only bedding type is easily manipulated to mitigate fighting. Cage ventilation and rack orientation often cannot be changed in modern vivaria, as they are baked in by cookie-cutter architectural approaches to facility design. This study emphasizes the need to invest in assessing the welfare costs of new housing and husbandry systems before implementing them.

Authors/Creators:Theil, Jacob H. and Ahloy-Dallaire, Jamie and Weber, Elin and Gaskill, Brianna N. and Pritchett-Corning, Kathleen R. and Felt, Stephen A. and Garner, Joseph P.
Title:The epidemiology of fighting in group-housed laboratory mice
Year of publishing :2020
Volume:10
Article number:16649
Number of Pages:10
Publisher:NATURE RESEARCH
ISSN:2045-2322
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
URN:NBN:urn:nbn:se:slu:epsilon-p-108670
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108670
Additional ID:
Type of IDID
DOI10.1038/s41598-020-73620-0
Web of Science (WoS)000578479400030
ID Code:18683
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Environment and Health
Deposited By: SLUpub Connector
Deposited On:17 Nov 2020 16:03
Metadata Last Modified:17 Nov 2020 16:11

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits