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Cytochrome P450 3A and ABC-transport proteins in horse

Tydén, Eva (2008). Cytochrome P450 3A and ABC-transport proteins in horse. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2008:93
ISBN 978-91-86195-26-7
[Doctoral thesis]

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Abstract

In this thesis cytochrome P450 3A (CYP3A) and the ABC-transport proteins P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), multidrug resistance protein 1 (MRP1) and multidrug resistance protein 2 (MRP2) have been studied in horse. In the first part of the thesis the gene and protein expression, cellular localization and metabolic activity of CYP3A were investigated in the intestines, liver and upper respiratory airways. High levels of CYP3A gene and protein expression and metabolic activity were found in the small intestines. The CYP3A-related activity in the upper respiratory airways was high in spite of rather low levels of CYP3A gene and protein expression. A possible explanation in this observation is that there is an efficient electron transport from NADPH P450 reductase and cytochrome b5 to CYP3A in these tissues. In the second part of the thesis gene and protein expression and cellular localization of P-gp, BCRP, MRP1 and MRP2 were studied in the intestines, liver and kidney. The expression and localization of the transporters in the tissues of horse showed both similarities and differences compared to other species. Collectively the results of the present thesis indicate that CYP3A and the examined ABC-transport proteins have important roles for bioavalability and elimination of substrate compounds in horse.

Authors/Creators:Tydén, Eva
Title:Cytochrome P450 3A and ABC-transport proteins in horse
Year of publishing :2008
Volume:2008:93
Number of Pages:85
Papers/manuscripts:
NumberReferences
ALLI. E. Tydén, L. Olsén, J. Tallkvist, P. Larsson, H. Tjälve (2004). CYP3A in horse intestines. Toxicology and Applied Pharmacology 201, 112-119. II. E. Tydén, H. Tjälve, P. Larsson. Characterization of CYP3A-Related Metabolism in Horse Intestines and Liver. (Submitted). III. E. Tydén, L. Olsén, J. Tallkvist, H. Tjälve, P. Larsson (2008). Cytochrome P450 3A, NADPH cytochrome P450 reductase and cytochrome b5 in the upper airways in horse. Research in Veterinary Science 85, 80-85. IV. E. Tydén, J. Tallkvist, H. Tjälve, P. Larsson (2008). P-glycoprotein in intestines, liver, kidney and lymphocytes in horse. Journal of Veterinary Pharmacology and Therapeutics online DOI: 10.1111/j.1365-2885.2008.01017.x. V. E. Tydén, H. Björnström, H. Tjälve, P. Larsson. Expression and localization of BCRP, MRP1 and MRP2 in intestines, liver and kidney in horse. (Manuscript).
Place of Publication:Uppsala
ISBN for printed version:978-91-86195-26-7
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agrovoc terms:horse, chytochrome p450, binding proteins, metabolism, intestines, kidney, liver, lungs, lymphocytes, gene expression
Keywords:horse, CYP3a, P-gp, BCRP, MRP1, MRP2, intestine, liver, kidney, upper respiratory airways, lymphocytes, brunner´s glands
URN:NBN:urn:nbn:se:slu:epsilon-2640
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-2640
ID Code:1900
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: Eva Tydén
Deposited On:03 Dec 2008 00:00
Metadata Last Modified:02 Dec 2014 10:15

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