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Alkylresorcinols as biomarkers of whole grain wheat and rye intake

Landberg, Rikard (2009). Alkylresorcinols as biomarkers of whole grain wheat and rye intake. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis Agriculturae Sueciae, 1652-6880 ; 2009:11
ISBN 978-91-86195-58-8
[Doctoral thesis]

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Dietary biomarkers are objective measures of food or nutrient intake and can be related to endpoints in epidemiological studies, used in the validation of dietary assessment instruments and used to check of compliance during intervention studies. Alkylresorcinols (AR), phenolic lipids present exclusively in the outer parts of wheat and rye grains, have been suggested as biomarkers of whole grain wheat and rye intake. The overall aim with this thesis was to evaluate AR as specific biomarkers of whole grain wheat and rye intake. This was conducted by developing a rapid GC-MS method for the analysis of AR in plasma and by studying AR pharmacokinetics, dose-response, reproducibility and relative validity in human intervention studies under controlled intake conditions. Factors affecting plasma AR concentrations were investigated in free-living Danish women. The method developed proved suitable for the analysis of relatively small sample volumes (50- 200μL). The results showed that AR in fasting plasma samples can be used as short-term concentration biomarkers, reflecting the intake range normally found in the Nordic countries in a dose-dependent manner. One or two repeated measurements of AR were found to adequately describe a subject’s average plasma AR concentration at regular and constant intake. In free-living Danish women, rye bread was identified as the major factor affecting plasma AR concentration and there was no evidence of non-dietary factors or other foods having an effect. In conclusion, our results support that AR can be used as biomarkers in intervention studies on whole grain wheat and rye and probably also in epidemiological endpoint- and validation studies.

Authors/Creators:Landberg, Rikard
Title:Alkylresorcinols as biomarkers of whole grain wheat and rye intake
Series Name/Journal:Acta Universitatis Agriculturae Sueciae
Year of publishing :2009
Number of Pages:95
ALLI) Landberg, R., Åman P. & Kamal-Eldin, A. (2008). A rapid GC-MS method for quantification of alkylresorcinols in human plasma. Analytical Biochemistry 385, 7-12. II) Landberg, R. Linko, A.M, Kamal-Eldin, A., Vessby, B., Adlercreutz, H. & Åman, P. (2006). Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran. Journal of Nutrition 136, 2760-2765. III) Landberg, R., Åman, P., Friberg, L., Vessby, B., Adlercreutz, H. & Kamal-Eldin, A. (2009). Dose-response of whole grain biomarkers: Alkylresorcinols in human plasma and their metabolites in urine in relation to intake. American Journal of Clinical Nutrition 89, 290-296. IV) Landberg, R., Kamal-Eldin, A., Andersson, A., Vessby, B. & Åman, P.(2008). Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: Plasma concentration and intake estimated from dietary records. American Journal of Clinical Nutrition 87, 832-838. V) Landberg, R., Kamal-Eldin, A., Zhang, J-X., Andersson, S-O.,Johansson, J-E., Hallmans, G. & Åman, P. Reproducibility of plasma alkylresorcinols during a 6-weeks rye intervention study on men with prostate cancer. Submitted. VI) Landberg, R., Kamal-Eldin, A., Åman, P., Christensen, J., Tjønneland,A., Overvad, K. & Olsen, A. Intake of rye bread is an important determinant of plasma alkylresorcinol concentration in Danish postmenopausal women. Manuscript.
Place of Publication:Uppsala
ISBN for printed version:978-91-86195-58-8
Publication Type:Doctoral thesis
Full Text Status:Public
Agrovoc terms:phenolic compounds, wheats, rye, food intake, digestive absorption, analytical methods
Keywords:Alkylresorcinols, AR, biomarker, whole grain, wheat, rye
Permanent URL:
ID Code:1931
Department:(NL, NJ) > Dept. of Food Science (until 161231)
Deposited By: Rikard Landberg
Deposited On:09 Feb 2009 00:00
Metadata Last Modified:02 Dec 2014 10:15

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