Home About Browse Search
Svenska


Specific shifts in the endocannabinoid system in hibernating brown bears

Boyer, Christian and Cussonneau, Laura and Brun, Charlotte and Deval, Christiane and Pais de Barros, Jean-Paul and Chanon, Stephanie and Bernoud-Hubac, Nathalie and Daira, Patricia and Evans, Alina L. and Arnemo, Jon and Swenson, Jon E. and Gauquelin-Koch, Guillemette and Simon, Chantal and Blanc, Stephane and Combaret, Lydie and Bertile, Fabrice and Lefai, Etienne (2020). Specific shifts in the endocannabinoid system in hibernating brown bears. Frontiers in Zoology. 17 , 35
[Journal article]

[img] PDF
1MB

Abstract

In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly drive physiological adaptation to the hibernating state. In hibernating brown bears (Ursus arctos), we hypothesized that beyond an overall suppression of the ECS, seasonal shift in endocannabinoids compounds could be linked to bear's peculiar features that include hibernation without arousal episodes and capacity to react to external disturbance. We explored circulating lipids in serum and the ECS in plasma and metabolically active tissues in free-ranging subadult Scandinavian brown bears when both active and hibernating. In winter bear serum, in addition to a 2-fold increase in total fatty acid concentration, we found significant changes in relative proportions of circulating fatty acids, such as a 2-fold increase in docosahexaenoic acid C22:6 n-3 and a decrease in arachidonic acid C20:4 n-6. In adipose and muscle tissues of hibernating bears, we found significant lower concentrations of 2-arachidonoylglycerol (2-AG), a major ligand of cannabinoid receptors 1 (CB1) and 2 (CB2). Lower mRNA level for genes encoding CB1 and CB2 were also found in winter muscle and adipose tissue, respectively. The observed reduction in ECS tone may promote fatty acid mobilization from body fat stores, and favor carbohydrate metabolism in skeletal muscle of hibernating bears. Additionally, high circulating level of the endocannabinoid-like compound N-oleoylethanolamide (OEA) in winter could favor lipolysis and fatty acid oxidation in peripheral tissues. We also speculated on a role of OEA in the conservation of an anorexigenic signal and in the maintenance of torpor during hibernation, while sustaining the capacity of bears to sense stimuli from the environment.

Authors/Creators:Boyer, Christian and Cussonneau, Laura and Brun, Charlotte and Deval, Christiane and Pais de Barros, Jean-Paul and Chanon, Stephanie and Bernoud-Hubac, Nathalie and Daira, Patricia and Evans, Alina L. and Arnemo, Jon and Swenson, Jon E. and Gauquelin-Koch, Guillemette and Simon, Chantal and Blanc, Stephane and Combaret, Lydie and Bertile, Fabrice and Lefai, Etienne
Title:Specific shifts in the endocannabinoid system in hibernating brown bears
Year of publishing :2020
Volume:17
Article number:35
Number of Pages:13
Publisher:BMC
ISSN:1742-9994
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Zoology
Keywords:Hibernation, Brown bear, Metabolism, Lipidomic, Docosahexaenoic acid, Endocannabinoid system, Cannabinoid receptor 1, Cannabinoid receptor 2, 2-arachidonoylglycerol, Anandamide, N-oleoylethanolamide
URN:NBN:urn:nbn:se:slu:epsilon-p-109382
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-109382
Additional ID:
Type of IDID
DOI10.1186/s12983-020-00380-y
Web of Science (WoS)000592113300001
ID Code:19780
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:28 Dec 2020 10:43
Metadata Last Modified:15 Jan 2021 19:20

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits