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Lactational transfer of cadmium in rodents - CNS effects in the offspring

Petersson Grawé, Kierstin (2003). Lactational transfer of cadmium in rodents - CNS effects in the offspring. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis Agriculturae Sueciae. Veterinaria, 1401-6257 ; 150
ISBN 91 576 6371 8
[Doctoral thesis]

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This thesis comprises studies on the transfer of cadmium (Cd) from the lactating dam to the suckling and CNS effects of Cd during development, using rodents as a model. The purpose has been to conduct low–level exposure studies relevant for risk assessment of Cd. Cadmium is recognised as a toxic environmental contaminant with renal dysfunction considered as the critical effect after long-term exposure. For the non-smoking, non-occupationally exposed population, food, especially of vegetable origin, is the main source of cadmium exposure. Cd concentration in suckling pup kidney was strongly correlated with Cd in milk and kidney of the Cd exposed lactating rats, showing that cadmium is transferred to the pup via milk and absorbed in the suckling. This indicates that Cd in kidney can be used as a biomarker of the Cd dose in pups. A prominent uptake and retention of Cd was demonstrated in the mammary tissue, where Cd binding to metallothionein was indicated. Cd in milk was present mainly in the fat and casein fractions with a smaller part in the whey fraction. The serotonergic system in the developing brain was found to be susceptible to Cd. Hippocampal and cortical levels of serotonin and its metabolite, 5-hydroxyindoleacetic acid, were markedly reduced in animals exposed via milk. The exposure did not cause any detectable levels of Cd in the brain. A positive linear correlation was revealed between spontaneous locomotor activity and kidney cadmium concentrations in pups exposed via milk. There were no effects on learning, memory or anxiety due to treatment. Effects on the fatty acid composition after Cd exposure were found in the liver and milk of the dams, and a minor modification was detected in the brain of the pups. The long-chain polyunsaturated fatty acids, which are important for normal development of the CNS, were unaltered, as were zinc levels in the brain. Probably, the observed CNS effects are due to a direct effect of very low levels of Cd in the developing brain. The results indicate that neurochemical and neurobehavioral effects during development may be a more sensitive endpoint for cadmium toxicity than renal dysfunction.

Authors/Creators:Petersson Grawé, Kierstin
Title:Lactational transfer of cadmium in rodents - CNS effects in the offspring
Series Name/Journal:Acta Universitatis Agriculturae Sueciae. Veterinaria
Year of publishing :March 2003
Number of Pages:41
ALLI. Petersson Grawé K, Oskarsson A. 2000. Cadmium in milk and mammary gland in rats and mice. Archives of Toxicology 73, 519-527. II. Andersson, H., Petersson Grawé, K., Lindqvist, E., Luthman, J., Oskarsson, A., Olson, L. 1997. Low-level cadmium exposure of lactating rats causes alterations in brain serotonin levels in the offspring. Neurotoxicology and Teratology 19, 105-115. III. Petersson Grawé, K. Teiling-Gårdlund, A., Jalkesten, E., Oskarsson, A. Neurobehavioral effects in rats postnatally exposed to cadmium via milk. Manuscript. IV. Petersson Grawé K, Pickova, J., Dutta, P., Oskarsson A. Fatty acid composition in liver and milk of cadmium exposed lactating rats and in brain of their offspring. Manuscript.
Place of Publication:Uppsala
ISBN for printed version:91 576 6371 8
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L51 Animal physiology - Nutrition
Subjects:Not in use, please see Agris categories
Agrovoc terms:neurotransmitters, toxicity, newborn animals, postnatal period, pollutants, heavy metals, cadmium, central nervous system, lactation, rodentia
Keywords:neurobehaviour, neurochemical, neurotransmitter, neurotoxicity, neonate, postnatal, pollutant, heavy metal, toxic metal
Permanent URL:
ID Code:199
Department:(VH) > Institutionen för farmakologi och toxikologi
Deposited By: Kierstin Petersson Grawé
Deposited On:28 Mar 2003 00:00
Metadata Last Modified:02 Dec 2014 10:02

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