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Antidepressant exposure causes a nonmonotonic reduction in anxiety-related behaviour in female mosquitofish

Martin, Jake M. and Nagarajan-Radha, Venkatesh and Tan, Hung and Bertram, Michael and Brand, Jack A. and Saaristo, Minna and Dowling, Damian K. and Wong, Bob B.M. (2020). Antidepressant exposure causes a nonmonotonic reduction in anxiety-related behaviour in female mosquitofish. Journal of hazardous materials letters. 1 , 100004
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Abstract

Worldwide, biologically active pharmaceuticals, such as psychoactive drugs, are routinely detected in aquatic ecosystems. In this regard, selective serotonin reuptake inhibitors (SSRIs), a class of antidepressant, are of major environmental concern. Through targeted action on evolutionarily conserved physiological pathways, SSRIs could alter ecologically important behaviours in exposed organisms. Here, using two field-realistic dosages (measured concentrations: 18 and 215 ng/L) of the SSRI fluoxetine (Prozac), we examined the effects of exposure on anxiety-related behaviours in wild-caught female mosquitofish, Gambusia holbrooki. Anxiety-related behaviour was assessed using a light/dark transition test, with the swimming activity of fish recorded under two alternating light conditions, complete darkness and bright light, with the shift in light condition used to induce an anxiety-like response. Fluoxetine exposure resulted in a nonmonotonic decrease in anxiety-related behaviour (i.e. nonlinear with dose), with fish in the low-fluoxetine treatment being less responsive to shifts in light condition compared to unexposed fish. There was no such difference between unexposed and high-exposed fish. Further, we detected a significant interaction between exposure treatment and fish weight on general swimming activity, suggesting the presence of a mass-specific effect of fluoxetine. More broadly, contaminant-induced disruption of animal behaviour—as documented here—could have wide-reaching effects on population-level fitness.

Authors/Creators:Martin, Jake M. and Nagarajan-Radha, Venkatesh and Tan, Hung and Bertram, Michael and Brand, Jack A. and Saaristo, Minna and Dowling, Damian K. and Wong, Bob B.M.
Title:Antidepressant exposure causes a nonmonotonic reduction in anxiety-related behaviour in female mosquitofish
Year of publishing :2020
Volume:1
Article number:100004
Number of Pages:6
ISSN:2666-9110
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmacology and Toxicology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:Boldness, Fish, Fluoxetine, Light/dark transition, SSRI, Swimming activity
URN:NBN:urn:nbn:se:slu:epsilon-p-108199
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108199
Additional ID:
Type of IDID
DOI10.1016/j.hazl.2020.100004
ID Code:20048
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:02 Jan 2021 06:05
Metadata Last Modified:02 Jan 2021 06:11

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