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Antimicrobial Resistance in Fecal Escherichia coli from Humans and Pigs at Farms at Different Levels of Intensification

Lunha, Kamonwan and Leangapichart, Thongpan and Jiwakanon, Jatesada and Angkititrakul, Sunpetch and Sunde, Marianne and Järhult, Josef D. and Ström Hallenberg, Gunilla and Hickman, Rachel A. and van Boeckel, Thomas and Magnusson, Ulf (2020). Antimicrobial Resistance in Fecal Escherichia coli from Humans and Pigs at Farms at Different Levels of Intensification. Antibiotics. 9 , 662
[Journal article]

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Abstract

The overall aim of the current study was to test the hypotheses that (i) antibiotic resistance in bacteria were more frequent in clinically health pigs in intensified company owned, medium-scale farms (MSFs) (100-500 sows) than in pigs in family-owned, small-scale farms (SSFs) (1-50 sows) and (ii) that farmers working at the MSFs were more prone to attain antibiotic resistant bacteria than farmers working at SSFs. The study was conducted in North-Eastern Thailand, comprising fecal Escherichia coli isolates from pigs, farmers working with the pigs (contact humans) and persons living in the same household as the farmer (non-contact humans) at 51 MSFs and 113 SSFs. Samples from all farms were also screened for methicillin-resistant staphylococcus aureus (MRSA), which was not detected in pig samples, but was found in one human sample. Susceptibility was tested by disc-diffusion for seven antibiotics commonly used in the study area. Resistance in pig isolates from MSFs were more frequent for chloramphenicol which (P < 0.001), trimethoprim/sulfamethoxazole (P < 0.001) and gentamicin (P < 0.05) compared with isolates from SSFs, whereas the opposite was true for tetracycline (P < 0.01). Resistance in the human isolates was lower than those in the isolates from pigs for tetracycline, trimethoprim/sulfamethoxazole and chloramphenicol (P < 0.001). The frequency of resistance in the contact human samples from SSFs and MSFs did not differ. There was no difference between isolates from contact and non-contact humans for any of the tested antibiotics. Multidrug resistance in isolates from pigs was 26%, significantly higher (P < 0.01) than the 13% from humans. The data indicate that (i) resistance to antibiotics, including those critical and highly important for human medicine, were more common in fecal E. coli from pigs at the MSFs than at the SSFs, whereas (ii) the resistance in fecal E. coli from pig farmers seemed not to be influenced by the level of intensification of the farm they were working at.

Authors/Creators:Lunha, Kamonwan and Leangapichart, Thongpan and Jiwakanon, Jatesada and Angkititrakul, Sunpetch and Sunde, Marianne and Järhult, Josef D. and Ström Hallenberg, Gunilla and Hickman, Rachel A. and van Boeckel, Thomas and Magnusson, Ulf
Title:Antimicrobial Resistance in Fecal Escherichia coli from Humans and Pigs at Farms at Different Levels of Intensification
Year of publishing :2020
Volume:9
Article number:662
Number of Pages:11
Publisher:MDPI
ISSN:2079-6382
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Public Health, Global Health, Social Medicine and Epidemiology
Keywords:antimicrobial resistance, pigs, farmers, Thailand, farming intensification
URN:NBN:urn:nbn:se:slu:epsilon-p-109457
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-109457
Additional ID:
Type of IDID
DOI10.3390/antibiotics9100662
Web of Science (WoS)000584234800001
ID Code:21126
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:08 Jan 2021 08:05
Metadata Last Modified:15 Jan 2021 19:26

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