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Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes

Zan, Yanjun and Carlborg, Orjan (2020). Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes. Genes. 11 , 1279
[Research article]

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Abstract

Variable individual responses to environmental changes, such as phenotype plasticity, are heritable, with some genotypes being robust and others plastic. This variation for plasticity contributes to variance in complex traits as genotype-by-environment interactions (G x E). However, the genetic basis of this variability in responses to the same external stimuli is still largely unknown. In an earlier study of a large haploid segregant yeast population, genotype-by-genotype-by-environment interactions were found to make important contributions to the release of genetic variation in growth responses to alterations of the growth medium. Here, we explore the genetic basis for heritable variation of different measures of phenotype plasticity in the same dataset. We found that the central loci in the environmentally dependent epistatic networks were associated with overall measures of plasticity, while the specific measures of plasticity identified a more diverse set of loci. Based on this, a rapid one-dimensional genome-wide association (GWA) approach to overall plasticity is proposed as a strategy to efficiently identify key epistatic loci contributing to the phenotype plasticity. The study thus provided both analytical strategies and a deeper understanding of the complex genetic regulation of phenotype plasticity in yeast growth.

Authors/Creators:Zan, Yanjun and Carlborg, Orjan
Title:Dissecting the Genetic Regulation of Yeast Growth Plasticity in Response to Environmental Changes
Series Name/Journal:Genes
Year of publishing :2020
Volume:11
Article number:1279
Number of Pages:13
Publisher:MDPI
ISSN:2073-4425
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:yeast growth, genotype by environment interactions, epistasis, genetic networks, phenotype plasticity
URN:NBN:urn:nbn:se:slu:epsilon-p-109807
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-109807
Additional ID:
Type of IDID
DOI10.3390/genes11111279
Web of Science (WoS)000593995600001
ID Code:21262
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Forest Genetics and Plant Physiology
Deposited By: SLUpub Connector
Deposited On:18 Jan 2021 13:43
Metadata Last Modified:18 Jan 2021 13:51

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