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Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database

Rose Vineer, Hannah and Morgan, Eric R. and Hertzberg, Hubertus and Bartley, David J. and Bosco, Antonio and Charlier, Johannes and Chartier, Christophe and Claerebout, Edwin and de Waal, Theo and Hendrickx, Guy and Hinney, Barbara and Höglund, Johan and Jezek, Jozica and Kasny, Martin and Keane, Orla M. and Martinez-Valladares, Maria and Mateus, Teresa Letra and McIntyre, Jennifer and Mickiewicz, Marcin and Munoz, Ana Maria and Phythian, Clare Joan and Ploeger, Harm W. and Rataj, Aleksandra Vergles and Skuce, Philip J. and Simin, Stanislav and Sotiraki, Smaragda and Spinu, Marina and Stuen, Snorre and Thamsborg, Stig Milan and Vadlejch, Jaroslav and Varady, Marian and von Samson-Himmelstjerna, Georg and Rinaldi, Laura (2020). Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database. Parasite. 27 , 69
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Abstract

Helminth infections are ubiquitous in grazing ruminant production systems, and are responsible for significant costs and production losses. Anthelmintic Resistance (AR) in parasites is now widespread throughout Europe, although there are still gaps in our knowledge in some regions and countries. AR is a major threat to the sustainability of modern ruminant livestock production, resulting in reduced productivity, compromised animal health and welfare, and increased greenhouse gas emissions through increased parasitism and farm inputs. A better understanding of the extent of AR in Europe is needed to develop and advocate more sustainable parasite control approaches. A database of European published and unpublished AR research on gastrointestinal nematodes (GIN) and liver fluke (Fasciola hepatica) was collated by members of the European COST Action "COMBAR" (Combatting Anthelmintic Resistance in Ruminants), and combined with data from a previous systematic review of AR in GIN. A total of 197 publications on AR in GIN were available for analysis, representing 535 studies in 22 countries and spanning the period 1980-2020. Reports of AR were present throughout the European continent and some reports indicated high within-country prevalence. Heuristic sample size-weighted estimates of European AR prevalence over the whole study period, stratified by anthelmintic class, varied between 0 and 48%. Estimated regional (country) prevalence was highly heterogeneous, ranging between 0% and 100% depending on livestock sector and anthelmintic class, and generally increased with increasing research effort in a country. In the few countries with adequate longitudinal data, there was a tendency towards increasing AR over time for all anthelmintic classes in GIN: aggregated results in sheep and goats since 2010 reveal an average prevalence of resistance to benzimidazoles (BZ) of 86%, macrocyclic lactones except moxidectin (ML) 52%, levamisole (LEV) 48%, and moxidectin (MOX) 21%. All major GIN genera survived treatment in various studies. In cattle, prevalence of AR varied between anthelmintic classes from 0-100% (BZ and ML), 0-17% (LEV) and 0-73% (MOX), and both Cooperia and Ostertagia survived treatment. Suspected AR in F. hepatica was reported in 21 studies spanning 6 countries. For GIN and particularly F. hepatica, there was a bias towards preferential sampling of individual farms with suspected AR, and research effort was biased towards Western Europe and particularly the United Kingdom. Ongoing capture of future results in the live database, efforts to avoid bias in farm recruitment, more accurate tests for AR, and stronger appreciation of the importance of AR among the agricultural industry and policy makers, will support more sophisticated analyses of factors contributing to AR and effective strategies to slow its spread.

Authors/Creators:Rose Vineer, Hannah and Morgan, Eric R. and Hertzberg, Hubertus and Bartley, David J. and Bosco, Antonio and Charlier, Johannes and Chartier, Christophe and Claerebout, Edwin and de Waal, Theo and Hendrickx, Guy and Hinney, Barbara and Höglund, Johan and Jezek, Jozica and Kasny, Martin and Keane, Orla M. and Martinez-Valladares, Maria and Mateus, Teresa Letra and McIntyre, Jennifer and Mickiewicz, Marcin and Munoz, Ana Maria and Phythian, Clare Joan and Ploeger, Harm W. and Rataj, Aleksandra Vergles and Skuce, Philip J. and Simin, Stanislav and Sotiraki, Smaragda and Spinu, Marina and Stuen, Snorre and Thamsborg, Stig Milan and Vadlejch, Jaroslav and Varady, Marian and von Samson-Himmelstjerna, Georg and Rinaldi, Laura
Title:Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database
Series Name/Journal:Parasite
Year of publishing :2020
Volume:27
Article number:69
Number of Pages:16
Publisher:EDP SCIENCES S A
ISSN:1252-607X
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:Anthelmintic resistance, Ruminants, Europe, Gastrointestinal nematodes, Liver fluke, Prevalence, Maps, Database
URN:NBN:urn:nbn:se:slu:epsilon-p-109943
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-109943
Additional ID:
Type of IDID
DOI10.1051/parasite/2020062
Web of Science (WoS)000595704600001
ID Code:21271
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:19 Jan 2021 10:23
Metadata Last Modified:19 Jan 2021 10:31

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