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Coliform mastitis in the sow

clinical immunological studies around parturition

Österlundh, Ingrid (2003). Coliform mastitis in the sow. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae. Veterinaria, 1401-6257 ; 146
ISBN 91-576-6363-7
[Doctoral thesis]

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Abstract

In the sow, acute coliform mastitis is the major cause of dysgalactia at parturition, a period when normal milk production is paramount for the survival of newborn piglets. Polymorphonuclear leukocytes (PMN) that phagocytose and kill bacteria is the first line of defence by the immune system against E. coli infection in the mammary gland. The overall aim of this thesis was to elucidate this aspect of the sow immune system around parturition in order to gain a better background understanding of the disease. The course of events regarding the number and function of leukocytes in the blood circulation and locally in the mammary gland was described in healthy sows around parturition. At parturition, PMN reached a peak in both blood and mammary secretion. The phagocytic capacity per PMN showed no change, nor did opsonic activity in serum, while the opsonic activity in mammary secretion increased after parturition. The sum effect of the variations on mammary gland defence mechanisms is not clear. The concentrations of oestradiol-17 β and cortisol were determined, and variations were seen in blood and mammary secretion. Directed migration and phagocytosis of PMN in colostrum and milk were compared. Chemoattractant properties of the two types of secretion were similar, while the phagocytic capacity of PMN was lower in colostrum, which may make sows more susceptible to coliform mastitis during the early postparturient period. The concentrations of oestradiol-17 β and cortisol were greater in colostrum. In a study of experimentally induced mastitis, prepartum opsonic activity in serum and functional capacity of PMN in the blood circulation were compared between sows that remained clinically healthy and sows that developed coliform mastitis after intramammary E. coli inoculation at parturition. The pre-inoculation chemotaxis, phagocytosis and expression of CD18 adhesion molecules did not differ between the two groups of sows. In contrast, the pre-inoculation opsonisation of E. coli tended to be better in serum from non-affected sows. Thus specific opsonins likely contribute to local protection of the mammary gland. Possibly, prepartum opsonic activity in serum can be used to predict predisposition to develop clinical mastitis in the peripartal sow. To conclude, no clear-cut evidence for a markedly depressed function of PMN was found in the mammary gland at parturition. No impaired functional capacity of PMN in the circulation was found before parturition in sows that developed mastitis after inoculation. However, the same sows had less opsonic activity for E. coli in serum before inoculation than non-affected sows, which might contribute to a susceptibility to clinical coliform mastitis.

Authors/Creators:Österlundh, Ingrid
Title:Coliform mastitis in the sow
Subtitle:clinical immunological studies around parturition
Year of publishing :April 2003
Volume:146
Number of Pages:34
Papers/manuscripts:
NumberReferences
ALLI. Österlundh, I., Holst, H., & Magnusson, U. 1998 Hormonal and immunological changes in blood and mammary secretion in the sow at parturition. Theriogenology 50, 465-477. II. Österlundh, I., Holst, H., & Magnusson, U. 2001 Effect of mammary secretions on functions of polymorphonuclear leukocytes in pigs. American Journal of Veterinary Research 62, 1250-1254. III. Österlundh, I., Hultén, F., Johannisson, A. & Magnusson, U. 2002 Sows intramammarily inoculated with Escherichia coli at parturition: I. Functional capacity of granulocytes in sows affected or non-affected by clinical mastitis. Veterinary Immunology and Immunopathology 90, 35-44. IV. Österlundh, I. & Magnusson, U. Can the opsonic activity in serum be used to predict the resistance to clinical mastitis in the peripartal sow?
Place of Publication:Uppsala
ISBN for printed version:91-576-6363-7
ISSN:1401-6257
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:Not in use, please see Agris categories
Agrovoc terms:sows, lactation, lactation disorders, coliform bacteria, mastitis, escherichia coli, animal diseases, immunity, granulocytes
Keywords:sow, mammary gland, leukocyte, neutrophil, granulocyte functions, coliform mastitis, E. coli, parturition, oestradiol-17 β, cortisol, experimental mastitis
URN:NBN:urn:nbn:se:slu:epsilon-166
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-166
ID Code:216
Department:(VH) > Institutionen för obstetrik och gynekologi
Deposited By: Staff Epsilon
Deposited On:04 Apr 2003 00:00
Metadata Last Modified:02 Dec 2014 10:02

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