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A WOX/Auxin Biosynthesis Module Controls Growth to Shape Leaf Form

Zhang, Zhongjuan and Runions, Adam and Mentink, Remco A. and Kierzkowski, Daniel and Karady, Michal and Hashemi, Babak and Huijser, Peter and Strauss, Soeren and Gan, Xiangchao and Ljung, Karin and Tsiantis, Miltos (2020). A WOX/Auxin Biosynthesis Module Controls Growth to Shape Leaf Form. Current Biology. 30 , 4857-+
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Abstract

A key challenge in biology is to understand how the regional control of cell growth gives rise to final organ forms. Plant leaves must coordinate growth along both the proximodistal and mediolateral axes to produce their final shape. However, the cell-level mechanisms controlling this coordination remain largely unclear. Here, we show that, in A. thaliana, WOX5, one of the WUSCHEL-RELATED HOMEOBOX (WOX) family of homeobox genes, acts redundantly with WOX1 and WOX3 (PRESSED FLOWER [PRS]) to control leaf shape. Through genetics and hormone measurements, we find that these WOXs act in part through the regional control of YUCCA (YUC) auxin biosynthetic gene expression along the leaf margin. The requirement for WOXmediated YUC expression in patterning of leaf shape cannot be bypassed by the epidermal expression of YUC, indicating that the precise domain of auxin biosynthesis is important for leaf form. Using time-lapse growth analysis, we demonstrate that WOX-mediated auxin biosynthesis organizes a proximodistal growth gradient that promotes lateral growth and consequently the characteristic ellipsoid A. thaliana leaf shape. We also provide evidence that WOX proteins shape the proximodistal gradient of differentiation by inhibiting differentiation proximally in the leaf blade and promoting it distally. This regulation allows sustained growth of the blade and enables a leaf to attain its final form. In conclusion, we show that the WOX/auxin regulatory module shapes leaf form by coordinating growth along the proximodistal and mediolateral leaf axes.

Authors/Creators:Zhang, Zhongjuan and Runions, Adam and Mentink, Remco A. and Kierzkowski, Daniel and Karady, Michal and Hashemi, Babak and Huijser, Peter and Strauss, Soeren and Gan, Xiangchao and Ljung, Karin and Tsiantis, Miltos
Title:A WOX/Auxin Biosynthesis Module Controls Growth to Shape Leaf Form
Series Name/Journal:Current Biology
Year of publishing :2020
Volume:30
Page range:4857-+
Number of Pages:18
Publisher:CELL PRESS
ISSN:0960-9822
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Cell Biology
URN:NBN:urn:nbn:se:slu:epsilon-p-110293
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-110293
Additional ID:
Type of IDID
DOI10.1016/j.cub.2020.09.037
Web of Science (WoS)000604622400005
ID Code:21798
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Forest Genetics and Plant Physiology
Deposited By: SLUpub Connector
Deposited On:29 Jan 2021 15:23
Metadata Last Modified:29 Jan 2021 15:31

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