Senanayake, Kanchana S. and Söderberg, Jonas and Polajev, Aleksei and Malmberg, Maja and Karunanayake, Eric H. and Tennekoon, Kamani H. and Samarakoon, Sameera R. and Bongcam-Rudloff, Erik and Niazi, Adnan
(2020).
The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites.
Genome Biology and Evolution. 12
, 3971-3976
[Research article]
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Abstract
Here we present the draft genome sequence of Setaria digitata, a parasitic nematode affecting cattle. Due to its similarity to Wuchereria bancrofti, the parasitic nematode that causes lymphatic filariasis in humans, S. digitata has been used as a model organism at the genomic level to find drug targets which can be used for the development of novel drugs and/or vaccines for human filariasis. Setaria digitata causes cerebrospinal nematodiasis in goats, sheep, and horses posing a serious threat to livestock in developing countries. The genome sequence of S. digitata will assist in finding candidate genes to use as drug targets in both S. digitata and W. bancrofti. The assembled draft genome is similar to 90 Mb long and contains 8,974 genomicscaffolds with a G+C content of 31.73%.
| Authors/Creators: | Senanayake, Kanchana S. and Söderberg, Jonas and Polajev, Aleksei and Malmberg, Maja and Karunanayake, Eric H. and Tennekoon, Kamani H. and Samarakoon, Sameera R. and Bongcam-Rudloff, Erik and Niazi, Adnan | ||||||
|---|---|---|---|---|---|---|---|
| Title: | The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites | ||||||
| Series Name/Journal: | Genome Biology and Evolution | ||||||
| Year of publishing : | 2020 | ||||||
| Volume: | 12 | ||||||
| Page range: | 3971-3976 | ||||||
| Number of Pages: | 6 | ||||||
| Publisher: | OXFORD UNIV PRESS | ||||||
| ISSN: | 1759-6653 | ||||||
| Language: | English | ||||||
| Publication Type: | Research article | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution-Noncommercial 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402) (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||
| Keywords: | Setaria digitata, cerebrospinal nematodiasis, setariosis, filariasis, helminth, genome, cattle parasite | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-105175 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-105175 | ||||||
| Additional ID: |
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| ID Code: | 21945 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Dept. of Animal Breeding and Genetics (VH) > Department of Biomedical Science and Veterinary Public Health | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 03 Feb 2021 04:03 | ||||||
| Metadata Last Modified: | 03 Feb 2021 06:01 |
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