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Markers of long term silent carriers of Streptococcus equiss p.equiin horses

Pringle, John and Venner, Monica and Tscheschlok, Lisa and Waller, Andrew S. and Riihimäki, Miia (2020). Markers of long term silent carriers of Streptococcus equiss p.equiin horses. Journal of Veterinary Internal Medicine. 34 , 2751-2757
[Research article]

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Abstract

Background Difficulty in detection of silent carriers ofStreptococcus equiis a key reason for its continued spread to immunologically naive groups of horses. Objective To determine whether clinical examination, markers of inflammation, or serology differentiate silent carriers ofS. equiin recovered comingled horses. Animals Ninety-eight warmblood yearlings and 72 unaffected mares on a large breeding farm (outbreak A), 38 mature Icelandic horses at a riding stable (outbreak B), and 27 mixed breed horses at a boarding stable (outbreak C). Methods Prospective observational study 6 months to 2 years after strangles outbreaks. Carriers were defined as any animal positive on culture or qPCR toS. equifrom nasopharyngeal lavage or guttural pouch endoscopy and lavage. Most horses had complete physical exams and 1 group included evaluation of white blood cell counts and serum amyloid A. Sera from all horses was tested for antibodies to antigens A and C ofS. equiusing an enhanced indirect ELISA. Descriptive statistics were calculated. Data were compared using pairedttests, Wilcoxon ranked test, chi square, or the Fishers exact test. Significance was set atP < .05. Results Apart from weanlings at 6 months in outbreak A, there was no significant association between any clinical markers or serology with carrier state (P= .06-1). Moreover, 3/12 culture positive carriers were seronegative toS. equi. Conclusions and Clinical Importance Silent carriers ofS. equido not differ clinically or on markers of inflammation to their noncarrier herd-mates. Moreover, serology alone will not distinguish carriers in comingled horses.

Authors/Creators:Pringle, John and Venner, Monica and Tscheschlok, Lisa and Waller, Andrew S. and Riihimäki, Miia
Title:Markers of long term silent carriers of Streptococcus equiss p.equiin horses
Series Name/Journal:Journal of Veterinary Internal Medicine
Year of publishing :2020
Volume:34
Page range:2751-2757
Number of Pages:7
Publisher:WILEY
ISSN:0891-6640
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:antigen A, antigen C, silent carrier, equine, iELISA, infection
URN:NBN:urn:nbn:se:slu:epsilon-p-108645
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108645
Additional ID:
Type of IDID
DOI10.1111/jvim.15939
Web of Science (WoS)000579184200001
ID Code:21949
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:03 Feb 2021 04:23
Metadata Last Modified:03 Feb 2021 06:01

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