Boswood, Adrian and Gordon, Sonya G. and Häggström, Jens and Vanselow, Martin and Wess, Gerhard and Stepien, Rebecca L. and Oyama, Mark A. and Keene, Bruce W. and Bonagura, John and MacDonald, Kristin A. and Patteson, Mark and Smith, Sarah and Fox, Philip R. and Sanderson, Karen and Woolley, Richard and Szatmari, Viktor and Menaut, Pierre and Church, Whitney M. and O'Sullivan, M. Lynne and Jaudon, Jean-Philippe and Kresken, Jan-Gerd and Rush, John and Barrett, Kirstie A. and Rosenthal, Steven L. and Saunders, Ashley B. and Bersås Ljungvall, Ingrid and Deinert, Michael and Bomassi, Eric and Estrada, Amara H. and Fernandez Del Palacio, Maria J. and Moise, N. Sydney and Abbott, Jonathan A. and Fujii, Yoko and Spier, Alan and Luethy, Michael W. and Santilli, Roberto A. and Uechi, Masami and Tidholm, Anna and Schummer, Christoph and Watson, Philip
(2020).
Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study.
Journal of Veterinary Internal Medicine. 34
, 1108-1118
[Research article]
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Abstract
Background The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF).Objectives To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF.Animals One hundred and thirty-five, and 73 dogs that did or did not develop CHF, respectively.Materials and methods The following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home-measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points.Results The most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF.Conclusions and Clinical Importance Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF.
| Authors/Creators: | Boswood, Adrian and Gordon, Sonya G. and Häggström, Jens and Vanselow, Martin and Wess, Gerhard and Stepien, Rebecca L. and Oyama, Mark A. and Keene, Bruce W. and Bonagura, John and MacDonald, Kristin A. and Patteson, Mark and Smith, Sarah and Fox, Philip R. and Sanderson, Karen and Woolley, Richard and Szatmari, Viktor and Menaut, Pierre and Church, Whitney M. and O'Sullivan, M. Lynne and Jaudon, Jean-Philippe and Kresken, Jan-Gerd and Rush, John and Barrett, Kirstie A. and Rosenthal, Steven L. and Saunders, Ashley B. and Bersås Ljungvall, Ingrid and Deinert, Michael and Bomassi, Eric and Estrada, Amara H. and Fernandez Del Palacio, Maria J. and Moise, N. Sydney and Abbott, Jonathan A. and Fujii, Yoko and Spier, Alan and Luethy, Michael W. and Santilli, Roberto A. and Uechi, Masami and Tidholm, Anna and Schummer, Christoph and Watson, Philip | ||||||
|---|---|---|---|---|---|---|---|
| Title: | Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study | ||||||
| Series Name/Journal: | Journal of Veterinary Internal Medicine | ||||||
| Year of publishing : | 2020 | ||||||
| Volume: | 34 | ||||||
| Page range: | 1108-1118 | ||||||
| Number of Pages: | 11 | ||||||
| Publisher: | WILEY | ||||||
| ISSN: | 0891-6640 | ||||||
| Language: | English | ||||||
| Publication Type: | Research article | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||
| Keywords: | canine, cardiovascular, clinical epidemiology, clinical trials, heart failure, physical examination, radiology and diagnostic imaging | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-105028 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-105028 | ||||||
| Additional ID: |
| ||||||
| ID Code: | 21958 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Dept. of Clinical Sciences | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 03 Feb 2021 06:03 | ||||||
| Metadata Last Modified: | 01 Aug 2021 16:30 |
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