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A review of congenital tremor type A-II in piglets

Stenberg, Hedvig and Jacobson, Magdalena and Malmberg, Maja (2020). A review of congenital tremor type A-II in piglets. Animal Health Research Reviews. 21 , PII S146625232000002X , 84-88
[Article Review/Survey]

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Congenital tremor (CT) is a neurological disease that affects new-born piglets. It was described in 1922 and six different forms, designated type AI-V and type B, are described based on the causative agents, as well as specific histological findings in the central nervous system (CNS). The various forms present with identical clinical signs consisting of mild to severe tremor of the head and body, sometimes complicated with ataxia. By definition, all A-forms have hypomyelination of the CNS, whereas there are no histopathological lesions with the B-form. The cause of the A-II form was long unknown, however, at present several different viruses have been proposed as the causative agent: porcine circovirus-II (PCV-II), astrovirus, PCV-like virus P1, and atypical porcine pestivirus (APPV). Currently, APPV is the only virus that has been proven to fulfill Mokili's Metagenomic Koch's Postulates. Following infection of the pregnant sow, the virus passes the placental barrier and infects the fetus. Interestingly, no clinical signs of disease have been associated with APPV in adult pigs. Furthermore, other viruses cannot be ruled out as additional potential causes of CT. Given the increased interest and research in CT type A-II, the aim of this review is to summarize current knowledge.

Authors/Creators:Stenberg, Hedvig and Jacobson, Magdalena and Malmberg, Maja
Title:A review of congenital tremor type A-II in piglets
Series Name/Journal:Animal Health Research Reviews
Year of publishing :2020
Article number:PII S146625232000002X
Number of Pages:5
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Congenital tremor, pestivirus, porcine, type A-II
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Additional ID:
Type of IDID
Web of Science (WoS)000583652800008
ID Code:22158
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:09 Feb 2021 07:55
Metadata Last Modified:09 Feb 2021 08:01

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