Wensman, Jonas Johansson and Stokstad, Maria
(2020).
Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model.
Pathogens. 9
, 991
[Article Review/Survey]
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Abstract
The current pandemic of COVID-19 has highlighted the importance of basic studies on coronaviruses (CoVs) in general, and severe acute respiratory syndrome CoV type 2 (SARS-CoV-2) in particular. CoVs have for long been studied in veterinary medicine, due to their impact on animal health and welfare, production, and economy. Several animal models using coronaviral disease in the natural host have been suggested. In this review, different animal models are discussed, with the main focus on bovine CoV (BCoV). BCoV is endemic in the cattle population worldwide and has been known and studied for several decades. SARS-CoV-2 and BCoV are both betacoronaviruses, where BCoV is highly similar to human coronavirus (HCoV) OC43, encompassing the same virus species (Betacoronavirus 1). BCoV causes respiratory and gastrointestinal disease in young and adult cattle. This review summarizes the current knowledge of the similarities and dissimilarities between BCoV and SARS-CoV-2, as well as discussing the usage of BCoV as a model for human CoVs, including SARS-CoV-2.
| Authors/Creators: | Wensman, Jonas Johansson and Stokstad, Maria | ||||||
|---|---|---|---|---|---|---|---|
| Title: | Could Naturally Occurring Coronaviral Diseases in Animals Serve as Models for COVID-19? A Review Focusing on the Bovine Model | ||||||
| Series Name/Journal: | Pathogens | ||||||
| Year of publishing : | 2020 | ||||||
| Volume: | 9 | ||||||
| Article number: | 991 | ||||||
| Number of Pages: | 11 | ||||||
| Publisher: | MDPI | ||||||
| Language: | English | ||||||
| Publication Type: | Article Review/Survey | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||
| Keywords: | coronavirus, animal model, bovine, SARS-CoV-2, one health, respiratory infection, gastrointestinal infection | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-110480 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-110480 | ||||||
| Additional ID: |
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| ID Code: | 22199 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Dept. of Clinical Sciences | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 12 Feb 2021 12:03 | ||||||
| Metadata Last Modified: | 12 Feb 2021 12:11 |
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