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Integration of molecular profiles in a longitudinal wellness profiling cohort

Tebani, Abdellah and Gummesson, Anders and Zhong, Wen and Koistinen, Ina Schuppe and Lakshmikanth, Tadepally and Olsson, Lisa M. and Boulund, Fredrik and Neiman, Maja and Stenlund, Hans and Hellstrom, Cecilia and Karlsson, Max J. and Arif, Muhammad and Dodig-Crnkovic, Tea and Mardinoglu, Adil and Lee, Sunjae and Zhang, Cheng and Chen, Yang and Olin, Axel and Mikes, Jaromir and Danielsson, Hanna and von Feilitzen, Kalle and Jansson, Per-Anders and Angeras, Oskar and Huss, Mikael and Kjellqvist, Sanela and Odeberg, Jacob and Edfors, Fredrik and Tremaroli, Valentina and Forsstrom, Bjorn and Schwenk, Jochen M. and Nilsson, Peter and Moritz, Thomas and Backhed, Fredrik and Engstrand, Lars and Brodin, Petter and Bergstrom, Goran and Uhlen, Mathias and Fagerberg, Linn (2020). Integration of molecular profiles in a longitudinal wellness profiling cohort. Nature Communications. 11 , 4487
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Abstract

An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

Authors/Creators:Tebani, Abdellah and Gummesson, Anders and Zhong, Wen and Koistinen, Ina Schuppe and Lakshmikanth, Tadepally and Olsson, Lisa M. and Boulund, Fredrik and Neiman, Maja and Stenlund, Hans and Hellstrom, Cecilia and Karlsson, Max J. and Arif, Muhammad and Dodig-Crnkovic, Tea and Mardinoglu, Adil and Lee, Sunjae and Zhang, Cheng and Chen, Yang and Olin, Axel and Mikes, Jaromir and Danielsson, Hanna and von Feilitzen, Kalle and Jansson, Per-Anders and Angeras, Oskar and Huss, Mikael and Kjellqvist, Sanela and Odeberg, Jacob and Edfors, Fredrik and Tremaroli, Valentina and Forsstrom, Bjorn and Schwenk, Jochen M. and Nilsson, Peter and Moritz, Thomas and Backhed, Fredrik and Engstrand, Lars and Brodin, Petter and Bergstrom, Goran and Uhlen, Mathias and Fagerberg, Linn
Title:Integration of molecular profiles in a longitudinal wellness profiling cohort
Series Name/Journal:Nature Communications
Year of publishing :2020
Volume:11
Article number:4487
Number of Pages:14
Publisher:NATURE RESEARCH
ISSN:2041-1723
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Other Clinical Medicine
URN:NBN:urn:nbn:se:slu:epsilon-p-110692
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-110692
Additional ID:
Type of IDID
DOI10.1038/s41467-020-18148-7
Web of Science (WoS)000607103200020
ID Code:22535
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Forest Genetics and Plant Physiology
Deposited By: SLUpub Connector
Deposited On:20 Feb 2021 23:19
Metadata Last Modified:21 Feb 2021 06:01

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