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Homeostasis model assessment, serum insulin and their relation to body fat in cats

Strage, Emma and Ley, Charles and Forkman, Johannes and Öhlund, Malin and Stadig, Sarah and Bergh, Anna and Ley, Cecilia (2021). Homeostasis model assessment, serum insulin and their relation to body fat in cats. BMC Veterinary Research. 17 , 34
[Research article]

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Abstract

Background
Obesity is associated with insulin resistance (IR) and considered a risk factor for diabetes mellitus (DM) in cats. It has been proposed that homeostasis model assessment (HOMA-IR), which is the product of fasting serum insulin (mU/L) and glucose (mmol/L) divided by 22.5, can be used to indicate IR. The objectives of this study were threefold: (i) to evaluate associations between body fat, fasting insulin, and HOMA-IR, (ii) to determine population-based reference interval of HOMA-IR in healthy lean cats, and (iii) to evaluate biological variation of HOMA-IR and fasting insulin in cats.
Results
150 cats were grouped as lean or overweight based on body condition score and in 68 of the cats body fat percentage (BF%) was estimated by computed tomography. Fasting serum insulin and glucose concentrations were analysed. Statistical differences in HOMA-IR and insulin between overweight or lean cats were evaluated using Wilcoxon rank-sum test. Robust method with Box-Cox transformation was used for calculating HOMA-IR reference interval in healthy lean cats. Relations between BF% and HOMA-IR and insulin were evaluated by regression analysis. Restricted maximum likelihood ratio was used to calculate indices of biological variation of HOMA-IR and insulin in seven cats.
There were significant differences between groups with overweight cats (n = 77) having higher HOMA-IR (p < 0.0001) and insulin (p = 0.0002) than lean cats (n = 73). Reference interval for HOMA-IR in lean cats was 0.1–3.0. HOMA-IR and fasting insulin concentrations showed similar significant positive association with BF% (p = 0.0010 and p = 0.0017, respectively). Within-animal coefficient of variation of HOMA-IR and insulin was 51% and 49%, respectively.
Conclusions
HOMA-IR and fasting insulin higher in overweight than lean cats and correlate to BF%. The established population-based reference interval for HOMA-IR as well as the indices of biological variation for HOMA-IR and fasting insulin may be used when interpreting HOMA-IR and fasting insulin in cats. Further studies are needed to evaluate if HOMA-IR or fasting insulin is useful for identifying cats at risk of developing DM.

Authors/Creators:Strage, Emma and Ley, Charles and Forkman, Johannes and Öhlund, Malin and Stadig, Sarah and Bergh, Anna and Ley, Cecilia
Title:Homeostasis model assessment, serum insulin and their relation to body fat in cats
Series Name/Journal:BMC Veterinary Research
Year of publishing :2021
Volume:17
Article number:34
Number of Pages:10
ISSN:1746-6148
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-110737
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-110737
Additional ID:
Type of IDID
DOI10.1186/s12917-020-02729-1
ID Code:22657
Faculty:University Animal Hospital
VH - Faculty of Veterinary Medicine and Animal Science
NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:University Animal Hospital (UAH)
(VH) > Dept. of Clinical Sciences
(NL, NJ) > Dept. of Crop Production Ecology
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:24 Feb 2021 14:23
Metadata Last Modified:24 Feb 2021 14:31

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