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Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle

Hill, Sharon and Taparia, Tanvi and Ignell, Rickard (2021). Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle. BMC Genomics. 22 , 71
[Research article]

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Abstract

BackgroundIn the light of dengue being the fastest growing transmissible disease, there is a dire need to identify the mechanisms regulating the behaviour of the main vector Aedes aegypti. Disease transmission requires the female mosquito to acquire the pathogen from a blood meal during one gonotrophic cycle, and to pass it on in the next, and the capacity of the vector to maintain the disease relies on a sustained mosquito population.ResultsUsing a comprehensive transcriptomic approach, we provide insight into the regulation of the odour-mediated host- and oviposition-seeking behaviours throughout the first gonotrophic cycle. We provide clear evidence that the age and state of the female affects antennal transcription differentially. Notably, the temporal- and state-dependent patterns of differential transcript abundance of chemosensory and neuromodulatory genes extends across families, and appears to be linked to concerted differential modulation by subsets of transcription factors.ConclusionsBy identifying these regulatory pathways, we provide a substrate for future studies targeting subsets of genes across disparate families involved in generating key vector behaviours, with the goal to develop novel vector control tools.

Authors/Creators:Hill, Sharon and Taparia, Tanvi and Ignell, Rickard
Title:Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle
Series Name/Journal:BMC Genomics
Year of publishing :2021
Volume:22
Article number:71
Number of Pages:19
Publisher:BMC
ISSN:1471-2164
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
Keywords:Mosquito, Olfaction, Ontogeny, Chemosensory-related genes, Neuromodulatory genes, Transcription factors
URN:NBN:urn:nbn:se:slu:epsilon-p-110777
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-110777
Additional ID:
Type of IDID
DOI10.1186/s12864-020-07336-w
Web of Science (WoS)000612906500004
ID Code:22662
Faculty:LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap
Department:(LTJ, LTV) > Department of Plant Protection Biology
Deposited By: SLUpub Connector
Deposited On:25 Feb 2021 13:23
Metadata Last Modified:25 Feb 2021 13:31

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