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Nerve growth factor in the equine joint

Kendall, Anna and Nystrom, S. and Ekman, Stina and Hulten, Lm and Lindahl, A. and Hansson, E. and Skiöldebrand, Eva (2021). Nerve growth factor in the equine joint. Veterinary Journal. 267 , 105579
[Research article]

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Nerve growth factor (NGF) is a neurotrophin with many functions. In humans, it is involved in inflammation, nerve growth, apoptosis and pain signalling. Increased concentrations of NGF in synovial fluid has been shown in humans and dogs with osteoarthritis. Despite osteoarthritis being a common problem in horses, no studies have previously been published on NGF in the equine joint. The aim of this study was to quantify NGF in equine synovial fluid from healthy joints, acutely inflamed septic joints and joints with structural changes associated with osteoarthritis. A secondary aim was to identify the localisation of NGF and its two receptors, TrkA and p75(NTR) in healthy and osteoarthritic articular cartilage. NGF concentrations in synovial fluid from osteoarthritic joints (n = 27), septic joints (n = 9) and healthy joints (n = 16) were determined by ELISA. In addition, articular cartilage from osteoarthritic and healthy joints was examined for NGF, TrkA and P75(NTR) using immunohistochemistry staining. NGF was present in equine synovial fluid and articular cartilage. Compared to synovial fluid from healthy joints, NGF concentration was higher in synovial fluid from joints with structural osteoarthritic changes (P = 0.032) or acute septic inflammation (P = 0.006). In articular cartilage with severe osteoarthritic changes, there was more abundant positive immunohistochemistry staining for NGF and its receptors than in normal articular cartilage. Further studies should focus on identifying precursor forms of NGF, and on receptor expression and downstream signalling of TrkA and P75(NTR) in health and disease. (C) 2020 The Author(s). Published by Elsevier Ltd.

Authors/Creators:Kendall, Anna and Nystrom, S. and Ekman, Stina and Hulten, Lm and Lindahl, A. and Hansson, E. and Skiöldebrand, Eva
Title:Nerve growth factor in the equine joint
Series Name/Journal:Veterinary Journal
Year of publishing :2021
Article number:105579
Number of Pages:6
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
Keywords:Horse, Joint, Nerve, Growth factor, Osteoarthritis
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Additional ID:
Type of IDID
Web of Science (WoS)000604969400008
ID Code:22797
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:18 Mar 2021 15:43
Metadata Last Modified:18 Mar 2021 15:51

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