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Biochemical markers and genetic risk factors in canine tumors

Rivera, Patricio (2010). Biochemical markers and genetic risk factors in canine tumors. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2010:34
ISBN 978-91-576-7447-0
[Doctoral thesis]

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Abstract

One out of four dogs will develop cancer before the age of 10 years. Many of them will succumb to the disease. Risk factor analysis, tumor prevention, and ways to prognosticate already existing tumors in the individual patient, are important. Canine mammary tumors (CMTs) are the most common type of tumor in intact female dogs and constitute about half of all tumors in female dogs. About half of the CMTs are malignant. The origin of CMTs is considered to be complex, with tumor development likely influenced by both genetic and environmental factors. In Sweden 36% of English Springer spaniels (ESS) are diagnosed with CMTs, suggesting a genetic influence in this breed. Several risk factors predisposing to CMT have been identified, but the majority of inherited risk factors remain unknown. The aim of the research described in this thesis was to study biomarkers, epidemiology and genetic risk factors in canine tumors with the main focus in canine mammary tumors, using a population of a breed at high-risk for this disease in Sweden. In the first study, a study of a serum biomarker in canine tumors, serum thymidine kinase 1 (TK1) -activity in canine malignant lymphoma, leukemia and solid tumors using the standard TK REA and non-radiometric assays was performed. Serum TK1 was proven to be highly effective in diagnosing, prognosticating, and monitoring dogs with hematological neoplasias (lymphoma, leukemia), but the assay was ineffective in detecting TK1 activity in solid tumors such as CMTs. Clinical and histological characteristics of CMTs were described in a population of ESS dogs in Sweden. The reproductive status was shown as an important risk factor for MT development and age of onset and histological subtype affected the survival time after diagnosis of MT-affected dogs. Genetic risk factors for CMTs were further investigated in the following studies. A candidate gene association study in CMTs showed two human breast cancer genes, BRCA1 and BRCA2 that were associated with CMT in ESS dogs. The potential involvement of the major histocompatibility complex (MHC) class II in CMT development was studied and the results indicated diversity of MHC class II haplotypes and identified a haplotype that protected against MT development in ESS dogs. In summary, this thesis provides new information about risk factors for CMT development. The identification of genetic risk factors is critical to improvements in prevention, diagnosis and treatment of these tumors.

Authors/Creators:Rivera, Patricio
Title:Biochemical markers and genetic risk factors in canine tumors
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :2010
Volume:2010:34
Number of Pages:82
Papers/manuscripts:
NumberReferences
I.Von Euler H, Rivera P, Aronsson A, Bengtsson C, Hansson L and Eriksson S. Monitoring therapy in canine malignant lymphoma and leukaemia with serum thymidine kinase 1 activity – evaluation of a new, fully automated non-radiometric assay. International Journal of Oncology 34: 505-510, 2008.
II.Rivera P, Fall T, Melin M, Lindblad-Toh K, Häggström J and von Euler H. Canine mammary tumors in a population of English Springer spaniels in Sweden. (Manuscript submitted for publication).
III.Rivera P, Melin M, Biagi T, Fall T, Häggström J, Lindblad-Toh K and von Euler H. Mammary tumor development in dogs is associated with BRCA1 and BRCA2. Cancer Research 69: 8770-8774, 2009.
IV.Rivera P, Melin M, Wilbe M, Häggström J, Lindblad-Toh K, Andersson G and von Euler H. Identification of a rare dog leukocyte antigen class II haplotype as a protective factor against canine mammary tumors. (Manuscript submitted for publication).
Place of Publication:Uppsala
Publisher:Department of Clinical Sciences, Swedish University of Agricultural Sciences
Associated Programs and Other Stakeholders:SLU - Research Areas for the Future > Future Animal Health and Welfare
ISBN for printed version:978-91-576-7447-0
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agrovoc terms:dogs, thymidine, neoplasms, diagnosis, therapy, genetic disorders, mammary gland diseases, histopathology, disease control, sweden
Keywords:Thymidine kinase 1, tumor marker, breast cancer, mammary neoplasia, dog, MHC class II, DLA, candidate gene, comparative oncology, BRCA1, BRCA2
URN:NBN:urn:nbn:se:slu:epsilon-3069
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-3069
ID Code:2280
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: Patricio Rivera
Deposited On:05 May 2010 00:00
Metadata Last Modified:02 Dec 2014 10:17

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