Mhd Omar, Nor Adila and Frank, Jan and Kruger, Johanita and Dal Bello, Federica and Medana, Claudio and Collino, Massimo and Zamaratskaia, Galia and Michaelsson, Karl and Wolk, Alicja and Landberg, Rikard
(2021).
Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model.
Molecular Nutrition and Food Research. 65
, 2001133
[Journal article]
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Abstract
Scope A high fructose and galactose intake show adverse metabolic effects in animal models and in humans, but it is yet unknown if addition of fermentable dietary fiber can mitigate such effects. This study investigate the effects of high intakes of fructose and galactose, with/without added fructooligosaccharides (FOS), on metabolic factors, inflammation, and gut integrity markers in rats.Methods and Results Rats (n = 6/group) receive different carbohydrates at isocaloric conditions for 12 weeks as follows: 1) starch (control), 2) fructose, 3) galactose, 4) starch + FOS (FOS control), 5) fructose + FOS, and 6) galactose + FOS, together with a high amount of n-6 polyunsaturated fatty acids (n-6 PUFA) in all diets except for in 7) starch + olive oil (negative control). The rats fed the galactose and galactose + FOS diets exhibit lower body weight than other groups. High-galactose diets has more pronounced effects on metabolic factors and gut permeability than high-fructose diets. High-fructose diets show less pronounced effect on these selected markers. No differences in inflammatory markers are detected for any of the diets.Conclusions The results suggest potential adverse effects of high galactose and fructose on metabolic factors and gut integrity markers, but not on inflammation. However, several mechanisms are at play, and general net effects are difficult to determine conclusively for the conditions tested.
Authors/Creators: | Mhd Omar, Nor Adila and Frank, Jan and Kruger, Johanita and Dal Bello, Federica and Medana, Claudio and Collino, Massimo and Zamaratskaia, Galia and Michaelsson, Karl and Wolk, Alicja and Landberg, Rikard | ||||||
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Title: | Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model | ||||||
Series Name/Journal: | Molecular Nutrition and Food Research | ||||||
Year of publishing : | 2021 | ||||||
Volume: | 65 | ||||||
Article number: | 2001133 | ||||||
Number of Pages: | 10 | ||||||
Publisher: | WILEY | ||||||
ISSN: | 1613-4125 | ||||||
Language: | English | ||||||
Publication Type: | Journal article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Nutrition and Dietetics | ||||||
Keywords: | fructooligosaccharides, fructose, galactose, gut integrity, inflammatory markers | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-111112 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111112 | ||||||
Additional ID: |
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ID Code: | 22804 | ||||||
Faculty: | NJ - Fakulteten för naturresurser och jordbruksvetenskap | ||||||
Department: | (NL, NJ) > Department of Molecular Sciences | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 19 Mar 2021 14:03 | ||||||
Metadata Last Modified: | 19 Mar 2021 14:11 |
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