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Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

Mhd Omar, Nor Adila and Frank, Jan and Kruger, Johanita and Dal Bello, Federica and Medana, Claudio and Collino, Massimo and Zamaratskaia, Galia and Michaelsson, Karl and Wolk, Alicja and Landberg, Rikard (2021). Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model. Molecular Nutrition and Food Research. 65 , 2001133
[Research article]

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Abstract

Scope A high fructose and galactose intake show adverse metabolic effects in animal models and in humans, but it is yet unknown if addition of fermentable dietary fiber can mitigate such effects. This study investigate the effects of high intakes of fructose and galactose, with/without added fructooligosaccharides (FOS), on metabolic factors, inflammation, and gut integrity markers in rats.Methods and Results Rats (n = 6/group) receive different carbohydrates at isocaloric conditions for 12 weeks as follows: 1) starch (control), 2) fructose, 3) galactose, 4) starch + FOS (FOS control), 5) fructose + FOS, and 6) galactose + FOS, together with a high amount of n-6 polyunsaturated fatty acids (n-6 PUFA) in all diets except for in 7) starch + olive oil (negative control). The rats fed the galactose and galactose + FOS diets exhibit lower body weight than other groups. High-galactose diets has more pronounced effects on metabolic factors and gut permeability than high-fructose diets. High-fructose diets show less pronounced effect on these selected markers. No differences in inflammatory markers are detected for any of the diets.Conclusions The results suggest potential adverse effects of high galactose and fructose on metabolic factors and gut integrity markers, but not on inflammation. However, several mechanisms are at play, and general net effects are difficult to determine conclusively for the conditions tested.

Authors/Creators:Mhd Omar, Nor Adila and Frank, Jan and Kruger, Johanita and Dal Bello, Federica and Medana, Claudio and Collino, Massimo and Zamaratskaia, Galia and Michaelsson, Karl and Wolk, Alicja and Landberg, Rikard
Title:Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model
Series Name/Journal:Molecular Nutrition and Food Research
Year of publishing :2021
Volume:65
Article number:2001133
Number of Pages:10
Publisher:WILEY
ISSN:1613-4125
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Nutrition and Dietetics
Keywords:fructooligosaccharides, fructose, galactose, gut integrity, inflammatory markers
URN:NBN:urn:nbn:se:slu:epsilon-p-111112
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111112
Additional ID:
Type of IDID
DOI10.1002/mnfr.202001133
Web of Science (WoS)000621422400001
ID Code:22804
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:19 Mar 2021 14:03
Metadata Last Modified:19 Mar 2021 14:11

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