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Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect

Mellgren, Torbjörn and Trbakovic, Amela and Thor, Andreas and Ekman, Stina and Ley, Cecilia and Öhman-Mägi, Caroline and Hammarström Johansson, Petra and Jensen-Waern, Marianne and Hedenqvist, Patricia (2021). Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect. Biomedical Materials. 16 , 035018
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Abstract

Long bone fractures are common and sometimes difficult to treat. Autologous bone (AB), bovine bone and calcium phosphates are used to stimulate bone growth with varying results. In the present study, a calcium phosphate cement (CPC) that previously showed promising grafting capabilities was evaluated for the first time in a long bone defect. A radius defect of 20 mm was created in 20 rabbits. The defect was filled by either a hollow CPC implant that had been manufactured as a replica of a rabbit radius through indirect 3D printing, or by particulate AB as control. Defect filling and bone formation was evaluated after 12 weeks by combining micro computed tomography (mu CT) and scoring of 3D images, together with histomorphometry and histology. The mu CT and histomorphometric evaluations showed a similar amount of filling of the defect (combining graft and bone) between the CPC and AB group, but the scoring of 3D images showed that the filling in the CPC group was significantly larger. Histologically the AB graft could not be distinguished from the new bone. The AB treated defects were found to be composed of more bone than the CPC group, including reorganised cancellous and cortical bone. Both the CPC and AB material was associated with new bone formation, also in the middle of the defect, which could result in closing of the otherwise critically sized gap. This study shows the potential for an indirectly 3D printed implant in guided bone regeneration in critically sized long bone defects.

Authors/Creators:Mellgren, Torbjörn and Trbakovic, Amela and Thor, Andreas and Ekman, Stina and Ley, Cecilia and Öhman-Mägi, Caroline and Hammarström Johansson, Petra and Jensen-Waern, Marianne and Hedenqvist, Patricia
Title:Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect
Series Name/Journal:Biomedical Materials
Year of publishing :2021
Volume:16
Article number:035018
Number of Pages:14
Publisher:IOP PUBLISHING LTD
ISSN:1748-6041
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 304 Medical Biotechnology > Biomaterials Science
Keywords:3D printing, bone augmentation, bone substitute, long bone, in vivo
URN:NBN:urn:nbn:se:slu:epsilon-p-111205
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111205
Additional ID:
Type of IDID
DOI10.1088/1748-605X/abde6f
Web of Science (WoS)000625123100001
ID Code:22850
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:29 Mar 2021 08:03
Metadata Last Modified:29 Mar 2021 08:11

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