Chumová, Jana and Kourová, Hana and Trögelová, Lucie and Daniel, Geoffrey and Binarová, Pavla
(2021).
γ-Tubulin Complexes and Fibrillar Arrays: Two Conserved High Molecular Forms with Many Cellular Functions.
Cells. 10
, 776
[Article Review/Survey]
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Abstract
Higher plants represent a large group of eukaryotes where centrosomes are absent. The functions of γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs) in metazoans and fungi in microtubule nucleation are well established and the majority of components found in the complexes are present in plants. However, plant microtubules are also nucleated in a γ-tubulin-dependent but γ-TuRC-independent manner. There is growing evidence that γ-tubulin is a microtubule nucleator without being complexed in γ-TuRC. Fibrillar arrays of γ-tubulin were demonstrated in plant and animal cells and the ability of γ-tubulin to assemble into linear oligomers/polymers was confirmed in vitro for both native and recombinant γ-tubulin. The functions of γ-tubulin as a template for microtubule nucleation or in promoting spontaneous nucleation is outlined. Higher plants represent an excellent model for studies on the role of γ-tubulin in nucleation due to their acentrosomal nature and high abundancy and conservation of γ-tubulin including its intrinsic ability to assemble filaments. The defining scaffolding or sequestration functions of plant γ-tubulin in microtubule organization or in nuclear processes will help our understanding of its cellular roles in eukaryotes.
Authors/Creators: | Chumová, Jana and Kourová, Hana and Trögelová, Lucie and Daniel, Geoffrey and Binarová, Pavla | ||||
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Title: | γ-Tubulin Complexes and Fibrillar Arrays: Two Conserved High Molecular Forms with Many Cellular Functions | ||||
Series Name/Journal: | Cells | ||||
Year of publishing : | 2021 | ||||
Volume: | 10 | ||||
Article number: | 776 | ||||
ISSN: | 2073-4409 | ||||
Language: | English | ||||
Publication Type: | Article Review/Survey | ||||
Article category: | Scientific peer reviewed | ||||
Version: | Published version | ||||
Copyright: | Creative Commons: Attribution 4.0 | ||||
Full Text Status: | Public | ||||
Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology | ||||
Keywords: | microtubules, plants, gamma-tubulin, gamma-tubulin complexes, fibrillar arrays, nucleation, signaling, sequestration | ||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-111316 | ||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111316 | ||||
Additional ID: |
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ID Code: | 23106 | ||||
Faculty: | S - Faculty of Forest Sciences | ||||
Department: | (S) > Department of Forest Biomaterials and Technology | ||||
Deposited By: | SLUpub Connector | ||||
Deposited On: | 08 Apr 2021 07:18 | ||||
Metadata Last Modified: | 08 Apr 2021 07:21 |
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