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Doing What Spiders Cannot-A Road Map to Supreme Artificial Silk Fibers

Johansson, Jan and Rising, Anna (2021). Doing What Spiders Cannot-A Road Map to Supreme Artificial Silk Fibers. ACS Nano. 15 , 1952-1959
[Research article]

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Abstract

Fabricating artificial spider silk fibers in bulk scale has been a major goal in materials science for centuries. Two main routes have emerged for making such fibers. One method uses biomimetics in which the spider silk proteins (spidroins) are produced under nativelike conditions and then spun into fibers in a process that captures the natural, complex molecular mechanisms. However, these fibers do not yet match the mechanical properties of native silk fibers, potentially due to the small size of the designed spidroin used. The second route builds on biotechnological progress that enables production of large spidroins that can be spun into fibers by using organic solvents. With this approach, fibers that equal the native material in terms of mechanical properties can be manufactured, but the yields are too low for economically sustainable production. Hence, the need for new ideas is urgent. Herein, we introduce a structural-biology-based approach for engineering artificial spidroins that circumvents the laws with which spidroins, being secretory proteins, have to comply in order to avoid membrane insertion and provide a road map to the production of biomimetic silk fibers with improved mechanical properties.

Authors/Creators:Johansson, Jan and Rising, Anna
Title:Doing What Spiders Cannot-A Road Map to Supreme Artificial Silk Fibers
Series Name/Journal:ACS Nano
Year of publishing :2021
Volume:15
Page range:1952-1959
Number of Pages:8
Publisher:AMER CHEMICAL SOC
ISSN:1936-0851
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 2 Engineering and Technology > 204 Chemical Engineering > Polymer Technologies
URN:NBN:urn:nbn:se:slu:epsilon-p-111349
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111349
Additional ID:
Type of IDID
DOI10.1021/acsnano.0c08933
Web of Science (WoS)000623061800005
ID Code:23113
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:08 Apr 2021 14:23
Metadata Last Modified:08 Apr 2021 14:31

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