Fellstrom, Bengt and Helmersson-Karlqvist, Johanna and Lind, Lars and Soveri, Inga and Thulin, Måns and Arnlov, Johan and Kultima, Kim and Larsson, Anders
(2021).
Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans.
Biomolecules. 11
, 396
[Research article]
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Abstract
The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the Prospective Investigation of the Vasculature in Uppsala Seniors Study (41 males and 49 females, all aged 75 years). Urinary cytokine levels were analyzed with two multiplex assays (proximity extension assays) and the cytokine levels were correlated with urine albumin. After adjustment for sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoking and multiplicity testing, 11 biomarkers remained significantly associated with urine albumin: thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor, matrix metalloproteinase-12 (MMP-12), C-X-C motif chemokine 9, tumor necrosis factor receptor superfamily member 11B, osteoprotegerin, growth-regulated alpha protein, C-X-C motif chemokine 6, oncostatin-M (OSM) and fatty acid-binding protein, intestinal, despite large differences in molecular weights. In this study, we found associations between urinary albumin and both small and large urine proteins. Additional studies are warranted to identify cytokine patterns and potential progression markers in various renal diseases.
Authors/Creators: | Fellstrom, Bengt and Helmersson-Karlqvist, Johanna and Lind, Lars and Soveri, Inga and Thulin, Måns and Arnlov, Johan and Kultima, Kim and Larsson, Anders | ||||||
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Title: | Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans | ||||||
Series Name/Journal: | Biomolecules | ||||||
Year of publishing : | 2021 | ||||||
Volume: | 11 | ||||||
Article number: | 396 | ||||||
Number of Pages: | 8 | ||||||
Publisher: | MDPI | ||||||
ISSN: | 2218-273X | ||||||
Language: | English | ||||||
Publication Type: | Research article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Urology and Nephrology | ||||||
Keywords: | glomerular injury, urine, thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-111357 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111357 | ||||||
Additional ID: |
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ID Code: | 23242 | ||||||
Faculty: | NJ - Fakulteten för naturresurser och jordbruksvetenskap | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 12 Apr 2021 08:23 | ||||||
Metadata Last Modified: | 12 Apr 2021 08:31 |
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