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Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans

Fellstrom, Bengt and Helmersson-Karlqvist, Johanna and Lind, Lars and Soveri, Inga and Thulin, Måns and Arnlov, Johan and Kultima, Kim and Larsson, Anders (2021). Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans. Biomolecules. 11 , 396
[Research article]

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Abstract

The aim of the present study was to study the associations between urine albumin excretion, and a large number of urinary chemokines, cytokines, and growth factors in a normal population. We selected 90 urine samples from individuals without CVD, diabetes, stroke or kidney disease belonging to the Prospective Investigation of the Vasculature in Uppsala Seniors Study (41 males and 49 females, all aged 75 years). Urinary cytokine levels were analyzed with two multiplex assays (proximity extension assays) and the cytokine levels were correlated with urine albumin. After adjustment for sex, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoking and multiplicity testing, 11 biomarkers remained significantly associated with urine albumin: thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor, matrix metalloproteinase-12 (MMP-12), C-X-C motif chemokine 9, tumor necrosis factor receptor superfamily member 11B, osteoprotegerin, growth-regulated alpha protein, C-X-C motif chemokine 6, oncostatin-M (OSM) and fatty acid-binding protein, intestinal, despite large differences in molecular weights. In this study, we found associations between urinary albumin and both small and large urine proteins. Additional studies are warranted to identify cytokine patterns and potential progression markers in various renal diseases.

Authors/Creators:Fellstrom, Bengt and Helmersson-Karlqvist, Johanna and Lind, Lars and Soveri, Inga and Thulin, Måns and Arnlov, Johan and Kultima, Kim and Larsson, Anders
Title:Albumin Urinary Excretion Is Associated with Increased Levels of Urinary Chemokines, Cytokines, and Growth Factors Levels in Humans
Series Name/Journal:Biomolecules
Year of publishing :2021
Volume:11
Article number:396
Number of Pages:8
Publisher:MDPI
ISSN:2218-273X
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Urology and Nephrology
Keywords:glomerular injury, urine, thrombospondin 2, interleukin 6, interleukin 8, hepatocyte growth factor
URN:NBN:urn:nbn:se:slu:epsilon-p-111357
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111357
Additional ID:
Type of IDID
DOI10.3390/biom11030396
Web of Science (WoS)000633429100001
ID Code:23242
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Deposited By: SLUpub Connector
Deposited On:12 Apr 2021 08:23
Metadata Last Modified:12 Apr 2021 08:31

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