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Shared Ancestry and Signatures of Recent Selection in Gotland Sheep

Ghoreishifar, Seyed Mohammad and Rochus, Christina Marie and Moghaddaszadeh-Ahrabi, Sima and Davoudi, Pourya and Salek Ardestani, Siavash and Johansson, Anna M. and Zinovieva, Natalia A. and Deniskova, Tatiana E. and Johansson, Anna Maria (2021). Shared Ancestry and Signatures of Recent Selection in Gotland Sheep. Genes. 12 , 433
[Research article]

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Abstract

Gotland sheep, a breed native to Gotland, Sweden (an island in the Baltic Sea), split from the Gute sheep breed approximately 100 years ago, and since, has probably been crossed with other breeds. This breed has recently gained popularity, due to its pelt quality. This study estimates the shared ancestors and identifies recent selection signatures in Gotland sheep using 600 K single nucleotide polymorphism (SNP) genotype data. Admixture analysis shows that the Gotland sheep is a distinct breed, but also has shared ancestral genomic components with Gute (similar to 50%), Karakul (similar to 30%), Romanov (similar to 20%), and Fjallnas (similar to 10%) sheep breeds. Two complementary methods were applied to detect selection signatures: A Bayesian population differentiation F-ST and an integrated haplotype homozygosity score (iHS). Our results find that seven significant SNPs (q-value < 0.05) using the F-ST analysis and 55 significant SNPs (p-value < 0.0001) using the iHS analysis. Of the candidate genes that contain significant markers, or are in proximity to them, we identify several belongings to the keratin genes, RXFP2, ADCY1, ENOX1, USF2, COX7A1, ARHGAP28, CRYBB2, CAPNS1, FMO3, and GREB1. These genes are involved in wool quality, polled and horned phenotypes, fertility, twining rate, meat quality, and growth traits. In summary, our results provide shared founders of Gotland sheep and insight into genomic regions maintained under selection after the breed was formed. These results contribute to the detection of candidate genes and QTLs underlying economic traits in sheep.

Authors/Creators:Ghoreishifar, Seyed Mohammad and Rochus, Christina Marie and Moghaddaszadeh-Ahrabi, Sima and Davoudi, Pourya and Salek Ardestani, Siavash and Johansson, Anna M. and Zinovieva, Natalia A. and Deniskova, Tatiana E. and Johansson, Anna Maria
Title:Shared Ancestry and Signatures of Recent Selection in Gotland Sheep
Series Name/Journal:Genes
Year of publishing :2021
Volume:12
Article number:433
Number of Pages:13
Publisher:MDPI
ISSN:2073-4425
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:Gotland sheep, population structure, pelt quality, selection signatures, BayeScan
URN:NBN:urn:nbn:se:slu:epsilon-p-111475
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111475
Additional ID:
Type of IDID
DOI10.3390/genes12030433
Web of Science (WoS)000633660400001
ID Code:23287
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:16 Apr 2021 14:23
Metadata Last Modified:16 Apr 2021 14:31

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