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Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection

Aboshady, Hadeer M. and Mandonnet, Nathalie and Johansson, Anna Maria and Jonas, Elisabeth and Bambou, Jean-Christophe (2021). Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection. PLoS ONE. 16 , e0248405
[Research article]

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Abstract

Gastrointestinal nematodes (GIN) are an important constraint in small ruminant production. Genetic selection for resistant animals is a potential sustainable control strategy. Advances in molecular genetics have led to the identification of several molecular genetic markers associated with genes affecting economic relevant traits. In this study, the variants in the genome of Creole goats resistant or susceptible to GIN were discovered from RNA-sequencing. We identified SNPs, insertions and deletions that distinguish the two genotypes, resistant and susceptible and we characterized these variants through functional analysis. The T cell receptor signalling pathway was one of the top significant pathways that distinguish the resistant from the susceptible genotype with 78% of the genes involved in this pathway showing genomic variants. These genomic variants are expected to provide useful resources especially for molecular breeding for GIN resistance in goats.

Authors/Creators:Aboshady, Hadeer M. and Mandonnet, Nathalie and Johansson, Anna Maria and Jonas, Elisabeth and Bambou, Jean-Christophe
Title:Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection
Series Name/Journal:PLoS ONE
Year of publishing :2021
Volume:16
Article number:e0248405
Number of Pages:14
Publisher:PUBLIC LIBRARY SCIENCE
ISSN:1932-6203
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-111491
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111491
Additional ID:
Type of IDID
DOI10.1371/journal.pone.0248405
Web of Science (WoS)000629667400016
ID Code:23290
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:19 Apr 2021 10:03
Metadata Last Modified:19 Apr 2021 10:11

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