Abstract

Gastrointestinal nematodes (GIN) are an important constraint in small ruminant production. Genetic selection for resistant animals is a potential sustainable control strategy. Advances in molecular genetics have led to the identification of several molecular genetic markers associated with genes affecting economic relevant traits. In this study, the variants in the genome of Creole goats resistant or susceptible to GIN were discovered from RNA-sequencing. We identified SNPs, insertions and deletions that distinguish the two genotypes, resistant and susceptible and we characterized these variants through functional analysis. The T cell receptor signalling pathway was one of the top significant pathways that distinguish the resistant from the susceptible genotype with 78% of the genes involved in this pathway showing genomic variants. These genomic variants are expected to provide useful resources especially for molecular breeding for GIN resistance in goats.

Published in

PLoS ONE
2021, Volume: 16, number: 3, article number: e0248405
Publisher: PUBLIC LIBRARY SCIENCE

SLU Authors

• Aboshady, Hadeer

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    
  • AgroParisTech
  • Cairo University
  • National Institute of Agricultural Research (INRA)

• Johansson, Anna Maria

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Jonas, Elisabeth

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Clinical Science


Publication identifier

DOI: https://doi.org/10.1371/journal.pone.0248405

Permanent link to this page (URI)

https://res.slu.se/id/publ/111491