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Faecal bacterial composition in horses with and without free faecal liquid: a case control study

Lindroth, Katrin and Dicksved, Johan and Pelve, Erik and Båverud, Viveca and Müller, Cecilia (2021). Faecal bacterial composition in horses with and without free faecal liquid: a case control study. Scientific Reports. 11 , 4745
[Research article]

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Abstract

Free faecal liquid (FFL) is a condition in horses which manifests as differential defecation of solid and liquid phases of faeces. The etiology of FFL is currently unknown, but deviances in the hindgut microbiota has been suggested to be of importance. The present study aimed to compare the faecal bacterial composition of farm-matched horses with (case, n=50) and without (control, n=50) FFL. Samples were collected at three different occasions. The V3 and V4 regions of the 16S rRNA gene were amplified and sequenced using Illumina sequencing. Also, samples were cultivated for detection of Clostridioides difficile and Clostridium perfringens. Analysis revealed similar faecal bacterial composition between case and control horses, but an effect of sampling period (p=0.0001). Within sampling periods, 14 genera were present in higher or lower proportions in case compared to control horses in at least one sampling period. Compared to controls, case horses had higher relative abundance of Alloprevotella (adjusted p<0.04) and lower relative abundance of Bacillus spp. (adjusted p<0.03) in at least two sampling periods. All horses tested negative for C. difficile and C. perfringens by culture of faeces. Further studies are required to establish the clinical relevance of specific bacterial taxa in FFL.

Authors/Creators:Lindroth, Katrin and Dicksved, Johan and Pelve, Erik and Båverud, Viveca and Müller, Cecilia
Title:Faecal bacterial composition in horses with and without free faecal liquid: a case control study
Series Name/Journal:Scientific Reports
Year of publishing :2021
Volume:11
Article number:4745
Number of Pages:10
Publisher:NATURE RESEARCH
ISSN:2045-2322
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-111547
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111547
Additional ID:
Type of IDID
DOI10.1038/s41598-021-83897-4
Web of Science (WoS)000626627700005
ID Code:23319
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Nutrition and Management
(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:22 Apr 2021 08:03
Metadata Last Modified:22 Apr 2021 08:11

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