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A QTL for conformation of back and croup influences lateral gait quality in Icelandic horses

Rosengren, Maria and Sigurðardóttir, Heiðrún and Eriksson, Susanne and Naboulsi, Rakan and Jouni, Ahmad and Novoa, Miguel and Albertsdóttir, Elsa and Kristjánsson, Þorvaldur and Rhodin, Marie and Viklund, Åsa and Velie, Brandon D. and Negro, Juan J. and Solé Berga, Marina and Lindgren, Gabriella (2021). A QTL for conformation of back and croup influences lateral gait quality in Icelandic horses. BMC Genomics. 22 , 267
[Research article]

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Abstract

Background
The back plays a vital role in horse locomotion, where the spine functions as a spring during the stride cycle. A complex interaction between the spine and the muscles of the back contribute to locomotion soundness, gait ability, and performance of riding and racehorses. Conformation is commonly used to select horses for breeding and performance in multiple horse breeds, where the back and croup conformation plays a significant role. The conformation of back and croup plays an important role on riding ability in Icelandic horses. However, the genes behind this trait are still unknown. Therefore, the aim of this study was to identify genomic regions associated with conformation of back and croup in Icelandic horses and to investigate their effects on riding ability. One hundred seventy-seven assessed Icelandic horses were included in the study. A genome-wide association analysis was performed using the 670 K+ Axiom Equine Genotyping Array, and the effects of different haplotypes in the top associated region were estimated for riding ability and additional conformation traits assessed during breeding field tests.
Results
A suggestive quantitative trait loci (QTL) for the score of back and croup was detected on Equus caballus (ECA) 22 (p-value = 2.67 × 10− 7). Haplotype analysis revealed two opposite haplotypes, which resulted in higher and lower scores of the back and croup, respectively (p-value < 0.001). Horses with the favorable haplotype were more inclined to have a well-balanced backline with an uphill conformation and had, on average, higher scores for the lateral gaits tölt (p-value = 0.02) and pace (p-value = 0.004). This genomic region harbors three genes: C20orf85, ANKRD60 and LOC100056167. ANKRD60 is associated with body height in humans. C20orf85 and ANKRD60 are potentially linked to adolescent idiopathic scoliosis in humans.
Conclusions
Our results show that the detected QTL for conformation of back and croup is of importance for quality of lateral gaits in Icelandic horses. These findings could result in a genetic test to aid in the selection of breeding horses, thus they are of major interest for horse breeders. The results may also offer a gateway to comparative functional genomics by potentially linking both motor laterality and back inclination in horses with scoliosis in humans.

Authors/Creators:Rosengren, Maria and Sigurðardóttir, Heiðrún and Eriksson, Susanne and Naboulsi, Rakan and Jouni, Ahmad and Novoa, Miguel and Albertsdóttir, Elsa and Kristjánsson, Þorvaldur and Rhodin, Marie and Viklund, Åsa and Velie, Brandon D. and Negro, Juan J. and Solé Berga, Marina and Lindgren, Gabriella
Title:A QTL for conformation of back and croup influences lateral gait quality in Icelandic horses
Series Name/Journal:BMC Genomics
Year of publishing :2021
Volume:22
Article number:267
Number of Pages:13
ISSN:1471-2164
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:Back, Backline, Conformation, Croup, High-density genome scan, Icelandic horse, Lateral gait quality, Novel QTL
URN:NBN:urn:nbn:se:slu:epsilon-p-111507
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111507
Additional ID:
Type of IDID
DOI10.1186/s12864-021-07454-z
ID Code:23352
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:26 Apr 2021 15:23
Metadata Last Modified:26 Apr 2021 15:31

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