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Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies

Valarcher, Jean-Francois and Hägglund, Sara and Näslund, Katarina and Jouneau, Luc and Malmström, Ester and Boulesteix, Olivier and Pinard, Anne and Leguere, Dany and Deslis, Alain and Gauthier, David and Dubuquoy, Catherine and Pietralunga, Vincent and Remot, Aude and Falk, Alexander and Shevchenko, Ganna and Bergstrom Lind, Sara and Von Brömssen, Claudia and Vargmar, Karin and Zhang, Baoshan and Kwong, Peter D. and Rodriguez, Maria Jose and Garcia Duran, Marga and Schwartz-Cornil, Isabelle and Taylor, Geraldine and Riffault, Sabine (2021). Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies. Vaccines. 9 , 236
[Research article]

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Abstract

The induction of long-lasting clinical and virological protection is needed for a successful vaccination program against the bovine respiratory syncytial virus (BRSV). In this study, calves with BRSV-specific maternally derived antibodies were vaccinated once, either with (i) a BRSV pre-fusion protein (PreF) and Montanide(TM) ISA61 VG (ISA61, n = 6), (ii) BRSV lacking the SH gene (Delta SHrBRSV, n = 6), (iii) a commercial vaccine (CV, n = 6), or were injected with ISA61 alone (n = 6). All calves were challenged with BRSV 92 days later and were euthanized 13 days post-infection. Based on clinical, pathological, and proteomic data, all vaccines appeared safe. Compared to the controls, PreF induced the most significant clinical and virological protection post-challenge, followed by Delta SHrBRSV and CV, whereas the protection of PreF-vaccinated calves was correlated with BRSV-specific serum immunoglobulin (Ig)G antibody responses 84 days post-vaccination, and the IgG antibody titers of Delta SHrBRSV- and CV-vaccinated calves did not differ from the controls on this day. Nevertheless, strong anamnestic BRSV- and PreF-specific IgG responses occurred in calves vaccinated with either of the vaccines, following a BRSV challenge. In conclusion, PreF and Delta SHrBRSV are two efficient one-shot candidate vaccines. By inducing a protection for at least three months, they could potentially improve the control of BRSV in calves.

Authors/Creators:Valarcher, Jean-Francois and Hägglund, Sara and Näslund, Katarina and Jouneau, Luc and Malmström, Ester and Boulesteix, Olivier and Pinard, Anne and Leguere, Dany and Deslis, Alain and Gauthier, David and Dubuquoy, Catherine and Pietralunga, Vincent and Remot, Aude and Falk, Alexander and Shevchenko, Ganna and Bergstrom Lind, Sara and Von Brömssen, Claudia and Vargmar, Karin and Zhang, Baoshan and Kwong, Peter D. and Rodriguez, Maria Jose and Garcia Duran, Marga and Schwartz-Cornil, Isabelle and Taylor, Geraldine and Riffault, Sabine
Title:Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies
Series Name/Journal:Vaccines
Year of publishing :2021
Volume:9
Article number:236
Number of Pages:27
Publisher:MDPI
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:respiratory syncytial virus, bovine, neonatal, subunit vaccine, pre-fusion, live-attenuated vaccine, deleted SHrBRSV, one-shot, duration of protection, correlate of protection
URN:NBN:urn:nbn:se:slu:epsilon-p-111627
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111627
Additional ID:
Type of IDID
DOI10.3390/vaccines9030236
Web of Science (WoS)000634198400001
ID Code:23414
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(VH) > Dept. of Clinical Sciences
(NL, NJ) > Dept. of Energy and Technology
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:04 May 2021 15:03
Metadata Last Modified:04 May 2021 15:11

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