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Recombination Events Shape the Genomic Evolution of Infectious Bronchitis Virus in Europe

Bali, Krisztina and Bálint, Adám and Farsang, Attila and Marton, Szilvia and Nagy, Borbala and Kaszab, Eszter and Belak, Sandor and Palya, Vilmos and Banyai, Krisztian (2021). Recombination Events Shape the Genomic Evolution of Infectious Bronchitis Virus in Europe. Viruses. 13 , 535
[Research article]

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Abstract

Infectious bronchitis of chicken is a high morbidity and mortality viral disease affecting the poultry industry worldwide; therefore, a better understanding of this pathogen is of utmost importance. The primary aim of this study was to obtain a deeper insight into the genomic diversity of field infectious bronchitis virus (IBV) strains using phylogenetic and recombination analysis. We sequenced the genome of 20 randomly selected strains from seven European countries. After sequencing, we created a genome sequence data set that contained 36 European origin field isolates and 33 vaccine strains. When analyzing these 69 IBV genome sequences, we identified 215 recombination events highlighting that some strains had multiple recombination breaking points. Recombination hot spots were identified mostly in the regions coding for non-structural proteins, and multiple recombination hot spots were identified in the nsp2, nsp3, nsp8, and nsp12 coding regions. Recombination occurred among different IBV genotypes and involved both field and vaccine IBV strains. Ninety percent of field strains and nearly half of vaccine strains showed evidence of recombination. Despite the low number and the scattered geographical and temporal origin of whole-genome sequence data collected from European Gammacoronaviruses, this study underlines the importance of recombination as a major evolutionary mechanism of IBVs.

Authors/Creators:Bali, Krisztina and Bálint, Adám and Farsang, Attila and Marton, Szilvia and Nagy, Borbala and Kaszab, Eszter and Belak, Sandor and Palya, Vilmos and Banyai, Krisztian
Title:Recombination Events Shape the Genomic Evolution of Infectious Bronchitis Virus in Europe
Series Name/Journal:Viruses
Year of publishing :2021
Volume:13
Article number:535
Number of Pages:13
Publisher:MDPI
ISSN:1999-4915
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area
Keywords:infectious bronchitis, genomic epidemiology, genomic evolution
URN:NBN:urn:nbn:se:slu:epsilon-p-111801
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111801
Additional ID:
Type of IDID
DOI10.3390/v13040535
Web of Science (WoS)000643797400001
ID Code:23488
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:14 May 2021 11:23
Metadata Last Modified:14 May 2021 11:31

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