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Exploring the Antibiotic Resistance Burden in Livestock, Livestock Handlers and Their Non-Livestock Handling Contacts: A One Health Perspective

Hickman, Rachel A. and Leangapichart, Thongpan and Lunha, Kamonwan and Jiwakanon, Jatesada and Angkititrakul, Sunpetch and Magnusson, Ulf and Sunde, Marianne and Jarhult, Josef D. (2021). Exploring the Antibiotic Resistance Burden in Livestock, Livestock Handlers and Their Non-Livestock Handling Contacts: A One Health Perspective. Frontiers in Microbiology. 12 , 651461
[Research article]

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Abstract

Antibiotics are freqeuently used in the livestock sector in low- and middle-income countries for treatment, prophylaxis, and growth promotion. However, there is limited information into the zoonotic prevalence and dissemination patterns of antimicrobial resistance (AMR) within these environments. In this study we used pig farming in Thailand as a model to explore AMR; 156 pig farms were included, comprising of small-sized (<50 sows) and medium-sized (>= 100 sows) farms, where bacterial isolates were selectively cultured from animal rectal and human fecal samples. Bacterial isolates were subjected to antimicrobial susceptibility testing (AST), and whole-genome sequencing. Our results indicate extensive zoonotic sharing of antibiotic resistance genes (ARGs) by horizontal gene transfer. Resistance to multiple antibiotics was observed with higher prevalence in medium-scale farms. Zoonotic transmission of colistin resistance in small-scale farms had a dissemination gradient from pigs to handlers to non-livestock contacts. We highly recommend reducing the antimicrobial use in animals' feeds and medications, especially the last resort drug colistin.

Authors/Creators:Hickman, Rachel A. and Leangapichart, Thongpan and Lunha, Kamonwan and Jiwakanon, Jatesada and Angkititrakul, Sunpetch and Magnusson, Ulf and Sunde, Marianne and Jarhult, Josef D.
Title:Exploring the Antibiotic Resistance Burden in Livestock, Livestock Handlers and Their Non-Livestock Handling Contacts: A One Health Perspective
Series Name/Journal:Frontiers in Microbiology
Year of publishing :2021
Volume:12
Article number:651461
Number of Pages:12
Publisher:FRONTIERS MEDIA SA
ISSN:1664-302X
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109)
Keywords:one-health approach, antibiotic resistance, zoonotic transmission, E, coli, livestock, pigs, meat-production
URN:NBN:urn:nbn:se:slu:epsilon-p-111918
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111918
Additional ID:
Type of IDID
DOI10.3389/fmicb.2021.651461
Web of Science (WoS)000646648000001
ID Code:23732
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:21 May 2021 11:23
Metadata Last Modified:21 May 2021 11:31

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