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Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses

Mitchell, Catriona and Steward, Karen F. and Charbonneau, Amelia R. L. and Walsh, Saoirse and Wilson, Hayley and Timoney, John F. and Wernery, Ulli and Joseph, Marina and Craig, David and van Maanen, Kees and Hoogkamer- van Gennep, Annelies and Leon, Albertine and Witkowski, Lucjan and Rzewuska, Magdalena and Stefanska, Ilona and Zychska, Monika and van Loon, Gunther and Cursons, Ray and Patty, Olivia and Acke, Els and Gilkerson, James R. and El-Hage, Charles and Allen, Joanne and Bannai, Hiroshi and Kinoshita, Yuta and Niwa, Hidekazu and Becu, Teotimo and Pringle, John and Guss, Bengt and Bose, Reinhard and Abbott, Yvonne and Katz, Lisa and Leggett, Bernadette and Buckley, Tom C. and Blum, Shlomo E. and Lopez, Fatima Cruz and Ros, Ana Fernandez and Campi, Maria Cristina Marotti and Preziuso, Silvia and Robinson, Carl and Newton, J. Richard and Schofield, Ellen and Brooke, Ben and Boursnell, Mike and de Brauwere, Nicolas and Kirton, Roxane and Barton, Charlotte K. and Abudahab, Khalil and Taylor, Ben and Yeats, Corin A. and Goater, Richard and Aanensen, David M. and Harris, Simon R. and Parkhill, Julian and Holden, Matthew T. G. and Waller, Andrew (2021). Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses. Microbial genomics. 7 , 000528
[Research article]

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Abstract

The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, Streptococcus equi subspecies equi, establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such ?carrier? animals appear healthy and are rarely identified during routine veterinary examinations pre- purchase or transit, but can transmit S. equi to na?ve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of S. equi recovered from 19 different countries using a new core- genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S. equi isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des ?pizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of S. equi and its close relative S. equi subspecies zooepidemicus that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact.

Authors/Creators:Mitchell, Catriona and Steward, Karen F. and Charbonneau, Amelia R. L. and Walsh, Saoirse and Wilson, Hayley and Timoney, John F. and Wernery, Ulli and Joseph, Marina and Craig, David and van Maanen, Kees and Hoogkamer- van Gennep, Annelies and Leon, Albertine and Witkowski, Lucjan and Rzewuska, Magdalena and Stefanska, Ilona and Zychska, Monika and van Loon, Gunther and Cursons, Ray and Patty, Olivia and Acke, Els and Gilkerson, James R. and El-Hage, Charles and Allen, Joanne and Bannai, Hiroshi and Kinoshita, Yuta and Niwa, Hidekazu and Becu, Teotimo and Pringle, John and Guss, Bengt and Bose, Reinhard and Abbott, Yvonne and Katz, Lisa and Leggett, Bernadette and Buckley, Tom C. and Blum, Shlomo E. and Lopez, Fatima Cruz and Ros, Ana Fernandez and Campi, Maria Cristina Marotti and Preziuso, Silvia and Robinson, Carl and Newton, J. Richard and Schofield, Ellen and Brooke, Ben and Boursnell, Mike and de Brauwere, Nicolas and Kirton, Roxane and Barton, Charlotte K. and Abudahab, Khalil and Taylor, Ben and Yeats, Corin A. and Goater, Richard and Aanensen, David M. and Harris, Simon R. and Parkhill, Julian and Holden, Matthew T. G. and Waller, Andrew
Title:Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses
Series Name/Journal:Microbial genomics
Year of publishing :2021
Volume:7
Article number:000528
Number of Pages:14
Publisher:MICROBIOLOGY SOC
ISSN:2057-5858
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
URN:NBN:urn:nbn:se:slu:epsilon-p-111859
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111859
Additional ID:
Type of IDID
DOI10.1099/mgen.0.000528
Web of Science (WoS)000641852800001
ID Code:23738
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:21 May 2021 13:23
Metadata Last Modified:21 May 2021 13:31

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