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Actinobacillus pleuropneumoniae

a major respiratory pathogen in pigs

Sjölund, Marie (2010). Actinobacillus pleuropneumoniae. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2010:73
ISBN 978-91-576-7518-7
[Doctoral thesis]

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Abstract

Actinobacillus pleuropneumoniae is a major cause of respiratory disease in pigs, causing animal suffering and substantial economic losses. The aim of this thesis was to obtain more knowledge on the protective immunity to infections with A. pleuropneumoniae and to evaluate potential strategies in preventing and combating A. pleuropneumoniae infections. Investigations regarding the role of maternal immunity for the protection of the offspring and the subsequent effect on the epidemiology on herd level demonstrated that the levels of serum antibodies to A. pleuropneumoniae in sows were reflected in colostral levels. The colostral levels were in turn reflected in the levels of serum antibodies in the offspring and piglets with high levels of antibodies also had detectable levels of antibodies for a longer time compared to the offspring to sows with low levels of antibodies to A. pleuropneumoniae. An inoculation of naïve pigs with A. pleuropneumoniae induced acute-phase protein responses. The response to the inoculation was clearly affected by the antimicrobial treatment administered at the onset of clinical signs of respiratory disease. The response of these pigs to a second inoculation was also influenced by the treatments carried out after the first inoculation. Enrofloxacin was superior in reducing clinical signs but left pigs unprotected at the second inoculation. Tetracycline demonstrated a similar treatment efficacy as enrofloxacin but pigs were protected at challenge as were the penicillin treated pigs. Penicillin was on the other hand not efficient in curing diseased pigs. The pigs that were protected from disease at the second inoculation had all developed serum antibodies to A. pleuropneumoniae following the first inoculation and an acute-phase response was not induced following the second inoculation. The results therefore indicate that antibodies mirror protection against disease well. Vaccinations against actinobacillosis in a fattening herd did not provide protection against clinical disease. However, in combination with intensified treatments of pigs with signs of respiratory disease, pleurisy registrations at slaughter decreased over time although the growth rate was unaffected.

Authors/Creators:Sjölund, Marie
Title:Actinobacillus pleuropneumoniae
Subtitle:a major respiratory pathogen in pigs
Year of publishing :2010
Volume:2010:73
Number of Pages:80
Papers/manuscripts:
NumberReferences
ALLI. Sjölund, M., Zoric, M., Persson, M., Karlsson, G. & Wallgren, P. (2010). Disease patterns and immune responses in the offspring to sows with high or low antibody levels to Actinobacillus pleuropneumoniae serotype 2. Research in Veterinary Science doi: 10.1016/j.rvsc.2010.07.025. II. Sjölund, M., Martín de la Fuente, A.J., Fossum, C. & Wallgren, P. (2009). Responses of pigs to a re-challenge with Actinobacillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure. Veterinary Record 164, 550-555. III. Sjölund, M., Fossum, C., Martín de la Fuente, A.J., Alava, M., Juul- Madsen, H.J., Lampreave, F., & Wallgren, P. Effects of various antimicrobial treatments on serum acute-phase responses and leukocyte counts in pigs after a primary and a secondary challenge infection with Actinobacillus pleuropneumoniae. (Submitted for publication). IV. Sjölund, M. & Wallgren, P. (2010). Field experience with two different vaccination strategies aiming to control infections with Actinobacillus pleuropneumoniae in a fattening pig herd. Acta Veterinaria Scandinavica 52:23.
Place of Publication:Uppsala
ISBN for printed version:978-91-576-7518-7
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agrovoc terms:swine, actinobacillus pleuropneumoniae, immunity, vaccination, disease control, animal health, immunology
Keywords:pig, Actinobacillus pleuropneumoniae, immunity, vaccination, acute-phase proteins, serology, antibody, DWG, antimicrobials, epidemiology, PRDC
URN:NBN:urn:nbn:se:slu:epsilon-3128
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-3128
ID Code:2399
Department:(VH) > Dept. of Clinical Sciences
Deposited By: Marie Sjölund
Deposited On:12 Nov 2010 00:00
Metadata Last Modified:02 Dec 2014 10:18

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