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Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits

Genova, Francesca and Nonnis, Simona and Maffioli, Elisa and Tedeschi, Gabriella and Strillacci, Maria Giuseppina and Carisetti, Michela and Sironi, Giuseppe and Cupaioli, Francesca Anna and Di Nanni, Noemi and Mezzelani, Alessandra and Mosca, Ettore and Helps, Christopher R. and Leegwater, Peter A. J. and Dorso, Laetitia and Buckley, Reuben M. and Aberdein, Danielle and Alves, Paulo C. and Ohlsson Andersson, Åsa and Barsh, Gregory S. and Bellone, Rebecca R. and Bergström, Tomas F. and Boyko, Adam R. and Brockman, Jeffrey A. and Casal, Margret L. and Castelhano, Marta G. and Distl, Ottmar and Dodman, Nicholas H. and Ellinwood, N. Matthew and Fogle, Jonathan E. and Forman, Oliver P. and Garrick, Dorian J. and Ginns, Edward and Haase, Bianca and Häggström, Jens and Harvey, Robert J. and Hasegawa, Daisuke and Hernandez, Isabel and Hytonen, Marjo K. and Kaukonen, Maria and Kaelin, Christopher B. and Kosho, Tomoki and Leclerc, Emilie and Lear, Teri L. and Leeb, Tosso and Li, Ronald H. L. and Lohi, Hannes and Magnuson, Mark A. and Malik, Richard and Mane, Shrinivasrao P. and Munday, John S. and Murphy, William J. and Pedersen, Niels C. and Peterson-Jones, Simon M. and Rothschild, Max F. and Rusbridge, Clare and Shapiro, Beth and Stern, Joshua A. and Swanson, William F. and Terio, Karen A. and Todhunter, Rory J. and Warren, Wesley C. and Wilcox, Elizabeth A. and Wildschutte, Julia H. and Yu, Yoshihiko and Lyons, Leslie A. and Longeri, Maria (2021). Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits. Scientific Reports. 11 , 8339
[Research article]

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Abstract

The amyloidoses constitute a group of diseases occurring in humans and animals that are characterized by abnormal deposits of aggregated proteins in organs, affecting their structure and function. In the Abyssinian cat breed, a familial form of renal amyloidosis has been described. In this study, multi-omics analyses were applied and integrated to explore some aspects of the unknown pathogenetic processes in cats. Whole-genome sequences of two affected Abyssinians and 195 controls of other breeds (part of the 99 Lives initiative) were screened to prioritize potential disease-associated variants. Proteome and miRNAome from formalin-fixed paraffin-embedded kidney specimens of fully necropsied Abyssinian cats, three affected and three non-amyloidosis-affected were characterized. While the trigger of the disorder remains unclear, overall, (i) 35,960 genomic variants were detected; (ii) 215 and 56 proteins were identified as exclusive or overexpressed in the affected and control kidneys, respectively; (iii) 60 miRNAs were differentially expressed, 20 of which are newly described. With omics data integration, the general conclusions are: (i) the familial amyloid renal form in Abyssinians is not a simple monogenic trait; (ii) amyloid deposition is not triggered by mutated amyloidogenic proteins but is a mix of proteins codified by wild-type genes; (iii) the form is biochemically classifiable as AA amyloidosis.

Authors/Creators:Genova, Francesca and Nonnis, Simona and Maffioli, Elisa and Tedeschi, Gabriella and Strillacci, Maria Giuseppina and Carisetti, Michela and Sironi, Giuseppe and Cupaioli, Francesca Anna and Di Nanni, Noemi and Mezzelani, Alessandra and Mosca, Ettore and Helps, Christopher R. and Leegwater, Peter A. J. and Dorso, Laetitia and Buckley, Reuben M. and Aberdein, Danielle and Alves, Paulo C. and Ohlsson Andersson, Åsa and Barsh, Gregory S. and Bellone, Rebecca R. and Bergström, Tomas F. and Boyko, Adam R. and Brockman, Jeffrey A. and Casal, Margret L. and Castelhano, Marta G. and Distl, Ottmar and Dodman, Nicholas H. and Ellinwood, N. Matthew and Fogle, Jonathan E. and Forman, Oliver P. and Garrick, Dorian J. and Ginns, Edward and Haase, Bianca and Häggström, Jens and Harvey, Robert J. and Hasegawa, Daisuke and Hernandez, Isabel and Hytonen, Marjo K. and Kaukonen, Maria and Kaelin, Christopher B. and Kosho, Tomoki and Leclerc, Emilie and Lear, Teri L. and Leeb, Tosso and Li, Ronald H. L. and Lohi, Hannes and Magnuson, Mark A. and Malik, Richard and Mane, Shrinivasrao P. and Munday, John S. and Murphy, William J. and Pedersen, Niels C. and Peterson-Jones, Simon M. and Rothschild, Max F. and Rusbridge, Clare and Shapiro, Beth and Stern, Joshua A. and Swanson, William F. and Terio, Karen A. and Todhunter, Rory J. and Warren, Wesley C. and Wilcox, Elizabeth A. and Wildschutte, Julia H. and Yu, Yoshihiko and Lyons, Leslie A. and Longeri, Maria
Title:Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits
Series Name/Journal:Scientific Reports
Year of publishing :2021
Volume:11
Article number:8339
Number of Pages:14
Publisher:NATURE RESEARCH
ISSN:2045-2322
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-112041
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112041
Additional ID:
Type of IDID
DOI10.1038/s41598-021-87168-0
Web of Science (WoS)000641790100005
ID Code:24206
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:31 May 2021 09:43
Metadata Last Modified:31 May 2021 09:51

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