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Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand

Huber, Laura and Hallenberg, Gunilla Strom and Lunha, Kamonwan and Leangapichart, Thongpan and Jiwakanon, Jatesada and Hickman, Rachel A. and Magnusson, Ulf and Sunde, Marianne and Jarhult, Josef D. and Van Boeckel, Thomas P. (2021). Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand. Frontiers in Veterinary Science. 8 , 659051
[Research article]

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Abstract

In Thailand, pig production has increased considerably in the last decades to meet a growing demand for pork. Antimicrobials are used routinely in intensive pig production to treat infections and increase productivity. However, the use of antimicrobials also contributes to the rise of antimicrobial resistance with potential consequences for animal and human health. Here, we quantify the association between antimicrobial use and resistance rates in extensive and intensive farms with a focus on geographic proximity between farm and drugstores. Of the 164 enrolled farms, 79% reported using antimicrobials for disease prevention, treatment, or as a feed additive. Antimicrobial-resistant E. coli were present in 63% of farms. These drugs included critically important antimicrobials, such as quinolones and penicillins. Medium-scale farms with intensive animal production practices showed higher resistance rates than small-scale farms with extensive practices. Farms with drug-resistant Escherichia coli were located closer to drugstores and a had a higher proportion of disease than farms without drug-resistant E. coli. We found no association between the presence of resistance in humans and antimicrobial use in pigs. Our findings call for actions to improve herd health to reduce the need for antimicrobials and systematic training of veterinarians and drugstore owners on judicious use of antimicrobials in animals to mitigate resistance.

Authors/Creators:Huber, Laura and Hallenberg, Gunilla Strom and Lunha, Kamonwan and Leangapichart, Thongpan and Jiwakanon, Jatesada and Hickman, Rachel A. and Magnusson, Ulf and Sunde, Marianne and Jarhult, Josef D. and Van Boeckel, Thomas P.
Title:Geographic Drivers of Antimicrobial Use and Resistance in Pigs in Khon Kaen Province, Thailand
Series Name/Journal:Frontiers in Veterinary Science
Year of publishing :2021
Volume:8
Article number:659051
Number of Pages:9
Publisher:FRONTIERS MEDIA SA
ISSN:2297-1769
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Escherichia coli, antimicrobial resistance, antimicrobial use, pig, intensive production
URN:NBN:urn:nbn:se:slu:epsilon-p-112140
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112140
Additional ID:
Type of IDID
DOI10.3389/fvets.2021.659051
Web of Science (WoS)000649285500001
ID Code:24421
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:08 Jun 2021 11:03
Metadata Last Modified:08 Jun 2021 11:11

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