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Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis

Dvorák Tomastíková, Eva and Hafrén, Anders and Trejo-Arellano, Minerva S. and Rasmussen, Sheena and Sato, Hikaru and Santos-González, Juan and Köhler, Claudia and Hennigs, Lars and Hofius, Daniel (2021). Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis. Plant Physiology. 185 , 2003-2021
[Research article]

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Abstract

The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expression of key developmental regulators. Previous work revealed that PRC2 also controls the onset of senescence, a form of developmental programmed cell death (PCD) in plants. Whether the induction of PCD in response to stress is similarly suppressed by the PRC2 remained largely unknown. In this study, we explored whether PCD triggered in response to immunity- and disease-promoting pathogen effectors is associated with changes in the distribution of the PRC2-mediated histone H3 lysine 27 trimethylation (H3K27me3) modification in Arabidopsis thaliana. We furthermore tested the distribution of the heterochromatic histone mark H3K9me2, which is established, to a large extent, by the H3K9 methyltransferase KRYPTONITE, and occupies chromatin regions generally not targeted by PRC2. We report that effector-induced PCD caused major changes in the distribution of both repressive epigenetic modifications and that both modifications have a regulatory role and impact on the onset of PCD during pathogen infection. Our work highlights that the transition to pathogen-induced PCD is epigenetically controlled, revealing striking similarities to developmental PCD.

Authors/Creators:Dvorák Tomastíková, Eva and Hafrén, Anders and Trejo-Arellano, Minerva S. and Rasmussen, Sheena and Sato, Hikaru and Santos-González, Juan and Köhler, Claudia and Hennigs, Lars and Hofius, Daniel
Title:Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-induced programmed cell death in Arabidopsis
Series Name/Journal:Plant Physiology
Year of publishing :2021
Volume:185
Page range:2003-2021
Number of Pages:19
ISSN:0032-0889
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Botany
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Developmental Biology
URN:NBN:urn:nbn:se:slu:epsilon-p-112179
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112179
Additional ID:
Type of IDID
DOI10.1093/plphys/kiab035
Web of Science (WoS)000649356200054
ID Code:24490
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Plant Biology and Forest Genetics (until 131231)
Deposited By: SLUpub Connector
Deposited On:09 Jun 2021 14:23
Metadata Last Modified:09 Jun 2021 14:32

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